The phasevarion: Phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes

Srikhanta, YN, Fox, KL and Jennings, MP (2010) The phasevarion: Phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes. Nature Reviews Microbiology, 8 3: 196-206. doi:10.1038/nrmicro2283


Author Srikhanta, YN
Fox, KL
Jennings, MP
Title The phasevarion: Phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes
Journal name Nature Reviews Microbiology   Check publisher's open access policy
ISSN 1740-1526
1740-1534
Publication date 2010-03-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrmicro2283
Open Access Status Not Open Access
Volume 8
Issue 3
Start page 196
End page 206
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
In several host-adapted pathogens, phase variation has been found to occur in genes that encode methyltransferases associated with type III restriction-modification systems. It was recently shown that in the human pathogens Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis phase variation of a type III DNA methyltransferase, encoded by members of the mod gene family, regulates the expression of multiple genes. This novel genetic system has been termed the 'phasevarion' (phase-variable regulon). The wide distribution of phase-variable mod family genes indicates that this may be a common strategy used by host-adapted bacterial pathogens to randomly switch between distinct cell types. © 2010 Macmillan Publishers Limited. All rights reserved.
Keyword Restriction-modification system
Outer-membrane protein
Adenine methylase mutants
Enterica serovar typhimurium
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Sun, 28 Feb 2010, 10:02:48 EST