Defining macropinocytosis

Kerr, M. C. and Teasdale, R. D. (2009) Defining macropinocytosis. Traffic, 10 4: 364-371. doi:10.1111/j.1600-0854.2009.00878.x

Author Kerr, M. C.
Teasdale, R. D.
Title Defining macropinocytosis
Journal name Traffic   Check publisher's open access policy
ISSN 1398-9219
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1600-0854.2009.00878.x
Open Access Status Not yet assessed
Volume 10
Issue 4
Start page 364
End page 371
Total pages 8
Editor Mark C. Marsh
Place of publication Malden MA, U.S.A.
Publisher Wiley-Blackwell Publishing
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
060108 Protein Trafficking
Abstract Macropinocytosis represents a distinct pathway of endocytosis in mammalian cells. This actin-driven endocytic process is not directly co-ordinated by the presence of cargo but can be induced upon activation of growth factor signalling pathways. The capacity to dissect the contribution of macropinocytosis to cellular processes has been hampered by a lack of unique molecular markers and defining features. While aspects of macropinosome formation and maturation are common to those shared by the other endocytic pathways, a number of key differences have recently begun to emerge and will be discussed in this study. It is now well established that macropinocytosis significantly contributes to antigen presentation by the immune system and is exploited by a range of pathogens for cellular invasion and avoidance of immune surveillance.
Keyword endocytosis
endosome maturation
pathogen invasion
sorting nexins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 277 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 278 times in Scopus Article | Citations
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Created: Mon, 15 Feb 2010, 20:14:18 EST by Susan Allen on behalf of Institute for Molecular Bioscience