Eradication of blastocystis carriage with antimicrobials: Reality or delusion?

Stensvold, CR, Smith, HV, Nagel, R, Olsen, KEP and Traub, RJ (2010) Eradication of blastocystis carriage with antimicrobials: Reality or delusion?. Journal of Clinical Gastroenterology, 44 2: 85-90. doi:10.1097/MCG.0b013e3181bb86ba

Author Stensvold, CR
Smith, HV
Nagel, R
Olsen, KEP
Traub, RJ
Title Eradication of blastocystis carriage with antimicrobials: Reality or delusion?
Formatted title
Eradication of blastocystis carriage with antimicrobials: Reality or delusion?
Journal name Journal of Clinical Gastroenterology   Check publisher's open access policy
ISSN 0192-0790
Publication date 2010-02-01
Year available 2010
Sub-type Article (original research)
DOI 10.1097/MCG.0b013e3181bb86ba
Volume 44
Issue 2
Start page 85
End page 90
Total pages 6
Place of publication Philadelphia, PA, U.S.A.
Publisher Lippincott Williams & Wilkins
Language eng
Subject 110803 Medical Parasitology
920105 Digestive System Disorders
Formatted abstract
Metronidazole constitutes a mainstay in the antimicrobial therapy of intestinal protozoa, and is also traditionally considered first-line therapy in cases where there is a requirement to treat Blastocystis, a common protist of disputable clinical significance. Many compounds have been used in attempts to eradicate the parasite, and an accumulating body of data indicates that successful antimicrobial eradication of Blastocystis is far from straightforward. This review focuses on some issues that prevent us from reaching a clear understanding of how to eradicate Blastocystis based on chemotherapeutic intervention, by focusing on conflicting reports on the efficacy of metronidazole and other compounds and study design and data limitations. The review provides a comprehensive overview of antimicrobials used to target Blastocystis, and discusses issues pertaining to drug resistance, treatment failure, and reinfection. Finally, key methodological and molecular diagnostic tools that will assist in the generation of data required to improve current knowledge are identified and discussed. Copyright © 2010 by Lippincott Williams & Wilkins.
Keyword Blastocystis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes CLINICAL REVIEW

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 07 Feb 2010, 10:04:39 EST