Attention-like deficit and hyperactivity in a Drosophila memory mutant

van Swinderen, Bruno and Brembs, Bjoern (2010) Attention-like deficit and hyperactivity in a Drosophila memory mutant. Journal of Neuroscience, 30 3: 1003-1014. doi:10.1523/JNEUROSCI.4516-09.2010

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Author van Swinderen, Bruno
Brembs, Bjoern
Title Attention-like deficit and hyperactivity in a Drosophila memory mutant
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2010-01-20
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4516-09.2010
Open Access Status File (Publisher version)
Volume 30
Issue 3
Start page 1003
End page 1014
Total pages 12
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Subject 1109 Neurosciences
Abstract The primary function of a brain is to produce adaptive behavioral choices by selecting the right action at the right time. In humans, attention determines action selection as well as memory formation, whereas memories also guide which external stimuli should be attended to (Chun and Turk-Browne, 2007). The complex codependence of attention, memory, and action selection makes approaching the neurobiological basis of these interactions difficult in higher animals. Therefore, a successful reductionist approach is to turn to simpler systems for unraveling such complex biological problems. In a constantly changing environment, even simple animals have evolved attention-like processes to effectively filter incoming sensory stimuli. These processes can be studied in the fruit fly, Drosophila melanogaster, by a variety of behavioral and electrophysiological techniques. Recent work has shown that mutations affecting olfactory memory formation in Drosophila also produce distinct defects in visual attention-like behavior (van Swinderen, 2007; van Swinderen et al., 2009). In this study, we extend those results to describe visual attention-like defects in the Drosophila memory consolidation mutant radish(1). In both behavioral and brain-recording assays, radish mutant flies consistently displayed responses characteristic of a reduced attention span, with more frequent perceptual alternations and more random behavior compared with wild-type flies. Some attention-like defects were successfully rescued by administering a drug commonly used to treat attention-deficit hyperactivity disorder in humans, methylphenidate. Our results suggest that a balance between persistence and flexibility is crucial for adaptive action selection in flies and that this balance requires radish gene function. Copyright © 2010 the authors
Keyword Consolidated memory
Olfactory memory
Flight simulator
Brain Activity
Term-memory
Radish
Melanogaster
Operant
Dopamine
Behavior
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 07 Feb 2010, 10:03:27 EST