Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides

Manvar, Atul, Malde, Alpeshkumar, Verma, Jitender, Virsodia, Vijay, Mishra, Arun, Upadhyay, Kuldip, Acharya, Hrishikesh, Coutinho, Evans and Shah, Anamik (2008) Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides. European Journal of Medicinal Chemistry, 43 11: 2395-2403. doi:10.1016/j.ejmech.2008.01.016


Author Manvar, Atul
Malde, Alpeshkumar
Verma, Jitender
Virsodia, Vijay
Mishra, Arun
Upadhyay, Kuldip
Acharya, Hrishikesh
Coutinho, Evans
Shah, Anamik
Title Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides
Journal name European Journal of Medicinal Chemistry   Check publisher's open access policy
ISSN 0223-5234
1768-3254
Publication date 2008-11-01
Sub-type Article (original research)
DOI 10.1016/j.ejmech.2008.01.016
Volume 43
Issue 11
Start page 2395
End page 2403
Total pages 9
Place of publication Paris, France
Publisher S.E.C.T.
Language eng
Subject 1101 Medical Biochemistry and Metabolomics
Abstract A set of 25 coumarin-4-acetic acid benzylidene hydrazides were synthesized and characterized by NMR, IR and mass spectroscopic techniques. The compounds were evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain using the BACTEC 460 system to determine percentage inhibition. To understand the relationship between structure and activity, a 3D-QSAR analysis has been carried out by Comparative Molecular Field Analysis (CoMFA). Several statistically significant CoMFA models were generated. The CoMFA model generated with database alignment was the best in terms of overall statistics. The CoMFA contours provide a good insight into the structure activity relationships of the compounds reported herein. 2008 Elsevier Masson SAS. All rights reserved.
Keyword Coumarin-hydrazides
Anti-tubercular activity
CoMFA
3D-QSAR study
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 04 Feb 2010, 00:22:16 EST by Macushla Boyle on behalf of Faculty of Science