Changing patterns of antiepileptic drug use in pregnant Australian women

Vajda, F. J. E., Hollingworth, S., Graham, J., Hitchcock, A. A., O'Brien, T. J., Lander, C. M. and Eadie, M. J. (2010) Changing patterns of antiepileptic drug use in pregnant Australian women. Acta Neurologica Scandinavica, 121 2: 89-93. doi:10.1111/j.1600-0404.2009.01260.x

Author Vajda, F. J. E.
Hollingworth, S.
Graham, J.
Hitchcock, A. A.
O'Brien, T. J.
Lander, C. M.
Eadie, M. J.
Title Changing patterns of antiepileptic drug use in pregnant Australian women
Journal name Acta Neurologica Scandinavica   Check publisher's open access policy
ISSN 0001-6314
Publication date 2010-02-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1600-0404.2009.01260.x
Open Access Status
Volume 121
Issue 2
Start page 89
End page 93
Total pages 5
Place of publication Oxford, England
Publisher Blackwell Publishing
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Objective –
To trace the pattern of antiepileptic drug (AED) use in pregnant Australian women annually from 1999 to 2007, and correlate it with the pattern of AED use in the wider community.

Methods –
Analysis of data from the Australian Register of AEDs in Pregnancy, related to Australian population data for AED prescriptions.

Results –
Over the study period, prescribing of carbamazepine, phenytoin and valproate for pregnant women decreased, and prescribing of lamotrigine, topiramate and levetiracetam increased. These changes tended to parallel prescribing trends in the wider community, except for valproate, whose prescribing in the overall community increased as its prescribing, and its dosage prescribed, decreased in pregnancy. Concomitant with this, there was a trend towards fewer births of foetuses with abnormalities.

Conclusions –
While otherwise following national AED prescribing trends, Australian prescribers are reducing the use and dose of valproate in pregnant women, likely in recognition of the teratogenic hazards of this drug.
Copyright © 2009 The Authors. 
Keyword Antiepileptic drugs
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 15 Dec 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 24 Jan 2010, 10:06:06 EST