Cellular redox regulation and prooxidant signaling systems: A new perspective on the free radical theory of aging

Linnane, Anthony W. and Eastwood, Hayden (2006) Cellular redox regulation and prooxidant signaling systems: A new perspective on the free radical theory of aging. Annals of the New York Academy of Sciences, 1067 47-55. doi:10.1196/annals.1354.008


Author Linnane, Anthony W.
Eastwood, Hayden
Title Cellular redox regulation and prooxidant signaling systems: A new perspective on the free radical theory of aging
Journal name Annals of the New York Academy of Sciences   Check publisher's open access policy
ISSN 0077-8923
1749-6632
ISBN 978-1-57331-599-9
Publication date 2006-05-01
Sub-type Article (original research)
DOI 10.1196/annals.1354.008
Volume 1067
Start page 47
End page 55
Total pages 9
Place of publication New York, U.S.A.
Publisher The New York Academy of Sciences
Language eng
Subject 0604 Genetics
0606 Physiology
Abstract The overarching role of coenzyme Q10 in gene regulation, bioenergy formation, cellular redox poise regulation, and hydrogen peroxide formation is presented. Coenzyme Q10 has a central role acting as a prooxidant in the generation of H2O2. Contrary to the dogma that superoxide and H2O2 formation are highly deleterious to cell survival this premise is rejected. Data are discussed that continuous superoxide and hydrogen peroxide formation are essential for normal cell function and that they play a major role in subcellular redox state modulation. It is the prooxidant activity of the so-called antioxidants that may be responsible for previously claimed benefits for high doses of oxido-reduction nutritional supplements such as alpha lipoic acid and coenzyme Q10. Oxygen-free radical formation is essential for the biological function and is not a direct causation of the mammalian aging process; aging is a multisystem stochastic process. © 2006 New York Academy of Sciences
Keyword Coenzyme Q10
Redox poise
Gene regulation
Hydrogen peroxide
Metabolic regulation
Antioxidants
Aging
Q-Index Code C1
Additional Notes Issue title: Understanding and modulating aging. Published Online: 10 May 2006

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 21 Jan 2010, 02:49:33 EST by Natalie Holt on behalf of Faculty Of Health Sciences