The functional assessment of cancer-vulvar: reliability and validity

Janda, Monika, Obermair, Andreas, Cellad, David, Nicklin, James, Perrin, Lewis, Ward, Bruce G., Crandon, Alexander J. and Trimmel, Michael (2005) The functional assessment of cancer-vulvar: reliability and validity. Gynecologic Oncology, 97 2: 568-575. doi:10.1016/j.ygyno.2005.01.047

Author Janda, Monika
Obermair, Andreas
Cellad, David
Nicklin, James
Perrin, Lewis
Ward, Bruce G.
Crandon, Alexander J.
Trimmel, Michael
Title The functional assessment of cancer-vulvar: reliability and validity
Journal name Gynecologic Oncology   Check publisher's open access policy
ISSN 0090-8258
Publication date 2005-05-01
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.ygyno.2005.01.047
Open Access Status
Volume 97
Issue 2
Start page 568
End page 575
Total pages 8
Place of publication New York , U.S.A.
Publisher Academic Press
Language eng
Subject 1112 Oncology and Carcinogenesis
Formatted abstract
To assess the reliability and validity of the Functional Assessment of Cancer Therapy-Vulvar (FACT-V).

Seventy-seven patients treated between January 1996 and January 2001 for cancer of the vulva completed the FACT-V, the Eastern Cooperative Oncology Group Performance Status Rating (ECOG-PSR) and the Hospital Anxiety and Depression Scale (HADS) once, 20 consecutive patients treated between February 2001 and October 2001 completed the questionnaires twice, once before surgery and at 2 months follow-up. The FACT-V scores were compared by patients' performance status, FIGO stage, recurrence, and age, and correlated to the HADS scores. Changes in the FACT-V from baseline to 2 months follow-up were evaluated to establish FACT-V's responsiveness to change.


The FACT-V's internal consistency was adequate (Chronbach's alpha range, 0.75 to 0.92). Patients with lower performance status, higher FIGO-stage or recurrent disease received lower FACT-V scores, indicating discriminant validity. The correlation between the FACT-V and the HADS were in the expected direction, indicating convergent and divergent validity. From pre- to post-surgery, scores in nine out of fifteen items of the vulvar cancer-specific subscale improved, while those of five items declined, indicating sensitivity of the vulvar cancer specific items to changes in patients' well-being.

The newly developed FACT-V provides a reliable and valid assessment of the quality of life of women with vulvar cancer. It can be used as a short measure of quality of life within research studies, and to facilitate communication about quality of life issues in clinical practice.
Copyright © 2005 Elsevier Inc. All rights reserved.

Keyword Vulvar cancer
Quality of life questionnaire
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 18 Jan 2010, 19:32:52 EST by Gerald Martin on behalf of Faculty Of Health Sciences