Continuing challenges in childhood non-Hodgkin’s lymphoma

Pinkerton, Ross (2005) Continuing challenges in childhood non-Hodgkin’s lymphoma. British Journal of Haematology, 130 4: 480-488. doi:10.1111/j.1365-2141.2005.05598.x


Author Pinkerton, Ross
Title Continuing challenges in childhood non-Hodgkin’s lymphoma
Journal name British Journal of Haematology   Check publisher's open access policy
ISSN 0007-1048
Publication date 2005-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1365-2141.2005.05598.x
Open Access Status Not Open Access
Volume 130
Issue 4
Start page 480
End page 488
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Blackwell
Language eng
Subject 1102 Cardiovascular Medicine and Haematology
Abstract Non-Hodgkin's lymphoma in children includes a number of different pathological subtypes and, with improved diagnostic techniques and better understanding of the natural history of each type, treatment strategies have become more tumour-specific. Original staging systems are now less useful in determining treatment stratification and there is a need for careful analysis of large cohorts of patients, treated in the same manner, to determine the clinical and biological features that, with current therapies, are of prognostic value. Novel imaging techniques, such as positron emission tomography, and molecular techniques to detect low-level marrow involvement are likely to be incorporated into new risk grouping. These will be used to determine the extent of initial disease and evaluate more accurately the speed and quality of response to chemotherapy. With high cure rates, it becomes particularly important to minimize late effects of therapy and the introduction of monoclonal antibodies in combination with chemotherapy may provide a method for improving outcome in poor risk groups and reducing sequelae by allowing reduction in chemotherapy in good risk patients. ©2005 Blackwell Publishing Ltd
Keyword Non-Hodgkin’s lymphoma
Childhood
Immunosuppression
Rituximab
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 14 Jan 2010, 20:54:52 EST by Simon Utteridge on behalf of Faculty Of Health Sciences