Role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer Disease patients

Pritchard, Antonia L., Pritchard, Colin W., Bentham, Peter and Lendon, Corinne L. (2007) Role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer Disease patients. Dementia and Geriatric Cognitive Disorders, 24 3: 201-206. doi:10.1159/000107081


Author Pritchard, Antonia L.
Pritchard, Colin W.
Bentham, Peter
Lendon, Corinne L.
Title Role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer Disease patients
Journal name Dementia and Geriatric Cognitive Disorders   Check publisher's open access policy
ISSN 1420-8008
1421-9824
Publication date 2007-08-01
Sub-type Article (original research)
DOI 10.1159/000107081
Volume 24
Issue 3
Start page 201
End page 206
Total pages 6
Place of publication Basel, Switzerland
Publisher S. Karger
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Background/Aims:
Alzheimer disease (AD) patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to BPSD development in AD has been demonstrated. This is an investigation of whether the linked polymorphic region and variable number tandem repeat variants of the serotonin transporter (SERT) are associated with BPSD.

Methods:
The longitudinal measures of BPSD of our large cohort of 367 AD patients were assessed by the Neuropsychiatric Inventory. Measures with good evidence of serotonergic involvement (delusions, hallucinations, depression, anxiety, agitation/aggression and irritability) were related to genotype and allele frequencies of the linked polymorphic region and variable number tandem repeat variants.

Results:
Analysis revealed significant relationships between the linked polymorphic region variant long allele with irritability and the variable number tandem repeat 10-repeat allele with psychosis, but no associations were found with depression, anxiety or agitation/aggression.

Conclusion:
Our data and review of previous studies suggest SERT could play a minor role in development of psychosis and aggressive/irritable tendencies; however, further investigations are required in large, well-characterized cohorts.

© 2007 S. Karger AG, Basel
Keyword Psychosis
Aggression
Irritability
Depression
SERT
5HTT and SLC6A4
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 13 Jan 2010, 23:37:49 EST by Jon Swabey on behalf of Faculty Of Health Sciences