Anti-histamines for prolonged non-specific cough in children

Chang, Anne B., Peake, Jane and McElrea, Margaret S. (2008) Anti-histamines for prolonged non-specific cough in children. Cochrane Database of Systematic Reviews, 2: CD005604.1-CD005604.27. doi:10.1002/14651858.CD005604.pub3

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ192262_OA.pdf application/pdf 378.64KB 0

Author Chang, Anne B.
Peake, Jane
McElrea, Margaret S.
Title Anti-histamines for prolonged non-specific cough in children
Journal name Cochrane Database of Systematic Reviews   Check publisher's open access policy
ISSN 1469-493X
Publication date 2008-02-23
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/14651858.CD005604.pub3
Open Access Status File (Publisher version)
Issue 2
Start page CD005604.1
End page CD005604.27
Total pages 27
Place of publication Oxford, United Kingdom
Publisher John Wiley & Sons
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Non-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. It is commonly seen in paediatric practice. These children are treated with a variety of therapies including anti-histamines. Also, anti-histamines are advocated as an empirical treatment in adults with chronic cough.

To evaluate the effectiveness of anti-histamines in treating children with prolonged non-specific cough.

Search strategy
We searched the Cochrane Register of Controlled Trials (CENTRAL), MEDLINE, OLDMEDLINE and EMBASE databases. The latest searches were performed in November 2008.

Selection criteria
All randomised controlled trials comparing anti-histamines with a placebo or placebo-like medication with cough as an outcome, where cough is not primarily related to an underlying respiratory disorder such as cystic fibrosis, asthma, or suppurative lung disease.

Data collection and analysis
Two review authors independently assessed study quality and extracted data.

Main results
Three included therapeutic studies had 182 randomised participants with 162 completing the trials although in one study, children with recurrent wheeze were also included. The four included safety evaluation studies randomised 3166 participants with 2862 completing the trials. Clinical heterogeneity was evident and limited data prevented combining data for meta-analysis. The two larger therapeutic studies described significant improvement in both the intervention and the placebo/placebo-like arms with no significant difference between the two groups. In the study with the smallest sample size, cetirizine (a second generation anti-histamine) was significantly more efficacious than placebo in reducing chronic cough in children associated with seasonal allergic rhinitis, and the effect was seen within two weeks of therapy. In contrast three of the larger evaluation studies that enrolled children with allergic rhinitis described a non-significant increase in cough as an adverse event. Combined data from the four safety evaluation studies revealed a non-significant difference between groups (OR 1.47 , 95% CI 0.86, 2.49) for cough as an adverse event but the trend favoured the placebo arm.

Authors' conclusions
This review has significant limitations. However, our finding of uncertain efficacy of anti-histamines for chronic cough are similar to that for acute cough in children. In contrast to recommendations in adults with chronic cough, anti-histamines cannot be recommended as empirical therapy for children with chronic cough. If anti-histamines were to be trialled in these children, current data suggest a clinical response (time to response) occurs within two weeks of therapy. However the use of anti-histamines in children with non-specific cough has to be balanced against the well known risk of adverse events especially in very young children.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article number CD005604 .Intervention Review. Review content assessed as up-to-date: 12 November 2009. Publication status and date: New search for studies and content updated (no change to conclusions), published in Issue 2, 2010.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 13 Jan 2010, 01:01:26 EST by Ms Lynette Adams on behalf of Rural Clinical School - Central Qld Region