Efficacy of a combination product containing pyrantel, febantel and praziquantel (DrontalA (R) Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs

Taweethavonsawat, Piyanan, Chungpivat, Sudchit, Satranarakun, Pakkawan, Traub, Rebecca J. and Schaper, Roland (2010) Efficacy of a combination product containing pyrantel, febantel and praziquantel (DrontalA (R) Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs. Parasitology Research, 106 2: 533-537. doi:10.1007/s00436-009-1665-9


Author Taweethavonsawat, Piyanan
Chungpivat, Sudchit
Satranarakun, Pakkawan
Traub, Rebecca J.
Schaper, Roland
Title Efficacy of a combination product containing pyrantel, febantel and praziquantel (DrontalA (R) Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs
Formatted title
Efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal® Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs
Journal name Parasitology Research   Check publisher's open access policy
ISSN 0932-0113
1432-1955
Publication date 2010-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s00436-009-1665-9
Open Access Status Not yet assessed
Volume 106
Issue 2
Start page 533
End page 537
Total pages 5
Editor B. Chobotar
H. Mehlhorn
Place of publication Berlin / Heidelberg
Publisher Springer
Language eng
Subject C1
Formatted abstract
Ancylostoma ceylanicum is a common hookworm of dogs, cats and humans in Asia. More recently, this hookworm was found to infect dogs in Australia. The objective of this study was to determine the efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal® Plus Flavour, Bayer) against A. ceylanicum in experimentally infected dogs. Twelve dogs were each subcutaneously injected with 300 infective third-stage larvae of A. ceylanicum. Pups were stratified by egg count and randomly allocated equally into control and treatment groups. The pups in the treatment group were treated orally at 20 days post-infection with a tablet containing pyrantel, febantel and praziquantel (Drontal® Plus Flavour, Bayer) with the recommended dose of one tablet per 10 kg bodyweight. The dogs in the control group were not treated. Egg counts were performed daily until the end of the study period and compared for the treated and control groups. No eggs were detected in the treated group of pups within 3 days of treatment, and faecal samples from this group remained negative throughout the rest of the study resulting in a treatment efficacy (egg reduction) of 100% (p  = 0.0011). The egg counts for the untreated group remained high for the rest of the study period. This trial demonstrated that a combination tablet containing pyrantel, febantel and praziquantel (Drontal® Plus Flavour, Bayer) given at the manufacturer’s recommended dose is effective against infection with A. ceylanicum in dogs.
© Springer-Verlag 2009.
Keyword Ancylostoma
Ancylostomiasis
Dog Diseases
Guanidines
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 13 November 2009

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 10 Jan 2010, 10:02:29 EST