Combination anti-inflammatory therapy: Synergism in rats of NSAIDs/corticosteroids with some herbal/animal products

Whitehouse, M. W. and Butters, D. E. (2003) Combination anti-inflammatory therapy: Synergism in rats of NSAIDs/corticosteroids with some herbal/animal products. Inflammopharmacology, 11 4-6: 453-464. doi:10.1163/156856003322699636


Author Whitehouse, M. W.
Butters, D. E.
Title Combination anti-inflammatory therapy: Synergism in rats of NSAIDs/corticosteroids with some herbal/animal products
Journal name Inflammopharmacology   Check publisher's open access policy
ISSN 0925-4692
1568-5608
Publication date 2003-12-01
Sub-type Article (original research)
DOI 10.1163/156856003322699636
Open Access Status Not yet assessed
Volume 11
Issue 4-6
Start page 453
End page 464
Total pages 12
Place of publication Basel, Switzerland
Publisher Birkhaeuser
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
Abstract A useful function of any complementary medicine is to supplement some of the benefits from other treatment modalities. In rats, extracts from Indian celery seed and the NZ green-lipped mussel are powerful nutraceuticals that (i) amplify the potency of salicylates and prednisone for treating pre-established chronic inflammation (arthritis, fibrosis) and (ii) reduce the steroid's gastrotoxic and lymphopenic side effects. Such combinations might also be useful for treating inflammatory components of (a) osteoarthritis caused by microcrystalline hydroxyapatite (BCP) and (b) pseudo-gout, associated with calcium pyrophosphate crystals; that are usually refractory to monotherapy.
Formatted abstract
A useful function of any complementary medicine is to supplement some of the benefits from other treatment modalities. In rats, extracts from Indian celery seed and the NZ green-lipped mussel are powerful nutraceuticals that (i) amplify the potency of salicylates and prednisone for treating pre-established chronic inflammation (arthritis, fibrosis) and (ii) reduce the steroid''s gastrotoxic and lymphopenic side effects. Such combinations might also be useful for treating inflammatory components of (a) osteoarthritis caused by microcrystalline hydroxyapatite (BCP) and (b) pseudo-gout, associated with calcium pyrophosphate crystals; that are usually refractory to monotherapy.
Keyword Collagen-induced arthritis
Celery seed extracts
NZ mussel extracts
Prednisone
BCP zymosan-induced fibrosis
Steroid-sparing activity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 06 Jan 2010, 19:41:53 EST by Natalie Holt on behalf of Faculty Of Health Sciences