Poly (ethylene glycol)layered silicate nanocomposites for retarded drug release prepared by hot-melt extrusion

Campbell, Kayleen, Craig, Duncan Q. M. and McNally, Tony (2008) Poly (ethylene glycol)layered silicate nanocomposites for retarded drug release prepared by hot-melt extrusion. International Journal of Pharmaceutics, 363 1-2: 126-131. doi:10.1016/j.ijpharm.2008.06.027


Author Campbell, Kayleen
Craig, Duncan Q. M.
McNally, Tony
Title Poly (ethylene glycol)layered silicate nanocomposites for retarded drug release prepared by hot-melt extrusion
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
1873-3476
Publication date 2008-11-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.ijpharm.2008.06.027
Open Access Status DOI
Volume 363
Issue 1-2
Start page 126
End page 131
Total pages 6
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 03 Chemical Sciences
0399 Other Chemical Sciences
Abstract Composites of paracetamol loaded previous termpolynext term(ethylene glycol) (PEG) with a naturally derived and partially synthetic layered silicate (nanoclay) were prepared using hot-melt extrusion. The extent of dispersion and distribution of the paracetamol and nanoclay in the PEG matrix was examined using a combination of field emission scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM) and wide-angle X-ray diffraction (WAXD). The paracetamol polymorph was shown to be well dispersed in the PEG matrix and the nanocomposite to have a predominately intercalated and partially exfoliated morphology. The form 1 monoclinic polymorph of the paracetamol was unaltered after the melt mixing process. The crystalline behaviour of the PEG on addition of both paracetamol and nanoclay was investigated using differential scanning calorimetry (DSC) and polarised hot-stage optical microscopy. The crystalline content of PEG decreased by up to 20% when both drug and nanoclay were melt blended with PEG, but the average PEG spherulite size increased by a factor of 4. The time taken for 100% release of paracetamol from the PEG matrix and corresponding diffusion coefficients were significantly retarded on addition of low loadings of both naturally occurring and partially synthetic nanoclays. The dispersed layered silicate platelets encase the paracetamol molecules, retarding diffusion and altering the dissolution behaviour of the drug molecule in the PEG matrix.
Keyword Poly(ethylene glycol)(PEG)
Nanocomposites
Drug delivery systems
Hot-melt extrusion
Layered silicates
Nanoclays
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemical Engineering Publications
 
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