Cultivating the uncultivated: A community genomics perspective

Tyson, Gene W. and Banfield, Jillian F. (2005) Cultivating the uncultivated: A community genomics perspective. Trends in Microbiology, 13 9: 411-415. doi:10.1016/j.tim.2005.07.003


Author Tyson, Gene W.
Banfield, Jillian F.
Title Cultivating the uncultivated: A community genomics perspective
Journal name Trends in Microbiology   Check publisher's open access policy
ISSN 0966-842X
Publication date 2005-09-01
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.tim.2005.07.003
Open Access Status Not yet assessed
Volume 13
Issue 9
Start page 411
End page 415
Total pages 5
Place of publication Cambridge, England
Publisher Elsevier Trends Journals
Language eng
Subject 03 Chemical Sciences
0304 Medicinal and Biomolecular Chemistry
0305 Organic Chemistry
Abstract Current isolation methods access only a small subset of the total microbial diversity. Although an isolate traditionally has been required for genomic characterization, the advent of sequencing of entire natural microbial communities enables culture-independent genomic analysis. Information about the genetic potential of uncultivated organisms can be used to predict the form of metabolic interdependencies and nutritional requirements. We believe that this could provide the information necessary to bypass bottlenecks that have inhibited cultivation of many microorganisms. However, it might not be practical or possible to isolate all of the vast number of microbial species and strains for laboratory-based characterization. Ultimately, cultivation- independent genomic and genomically enabled approaches could provide a way to directly analyze microbial activity in its geochemical and ecological context.
Keyword Genes
Genomics
Diversity
Communities
Interdependence
Nutrition
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 56 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 22 Dec 2009, 18:52:51 EST by Macushla Boyle on behalf of Faculty of Science