Involvement of notch signaling in wound healing

Chigurupati, Srinivasulu, Arumugam, Thiruma V., Son, Tae Gen, Lathia, Justin D., Jameel, Shafaq, Mughal, Mohamed R., Tang, Sung-Chun, Jo, Dong-Gyu, Camandola, Simonetta, Giunta, Marialuisa, Rakova, Irina, McDonnell, Nazli, Miele, Lucio, Mattson, Mark P. and Poosala, Suresh (2007) Involvement of notch signaling in wound healing. PLoS One, 2 11: e1167-1-e1167-9. doi:10.1371/journal.pone.0001167

Author Chigurupati, Srinivasulu
Arumugam, Thiruma V.
Son, Tae Gen
Lathia, Justin D.
Jameel, Shafaq
Mughal, Mohamed R.
Tang, Sung-Chun
Jo, Dong-Gyu
Camandola, Simonetta
Giunta, Marialuisa
Rakova, Irina
McDonnell, Nazli
Miele, Lucio
Mattson, Mark P.
Poosala, Suresh
Title Involvement of notch signaling in wound healing
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2007-11-14
Sub-type Article (original research)
DOI 10.1371/journal.pone.0001167
Open Access Status DOI
Volume 2
Issue 11
Start page e1167-1
End page e1167-9
Total pages 9
Place of publication San Francisco, CA, U.S.A.
Publisher Public Library of Science
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
Abstract The Notch signaling pathway is critically involved in cell fate decisions during development of many tissues and organs. In the present study we employed in vivo and cell culture models to elucidate the role of Notch signaling in wound healing. The healing of full-thickness dermal wounds was significantly delayed in Notch antisense transgenic mice and in normal mice treated with γ-secretase inhibitors that block proteolytic cleavage and activation of Notch. In contrast, mice treated with a Notch ligand Jagged peptide showed significantly enhanced wound healing compared to controls. Activation or inhibition of Notch signaling altered the behaviors of cultured vascular endothelial cells, keratinocytes and fibroblasts in a scratch wound healing model in ways consistent with roles for Notch signaling in wound healing functions all three cell types. These results suggest that Notch signaling plays important roles in wound healing and tissue repair, and that targeting the Notch pathway might provide a novel strategy for treatment of wounds and for modulation of angiogenesis in other pathological conditions.
Keyword Wound healing
Public health
Q-Index Code C1
Additional Notes Article - e1167

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 54 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 21 Dec 2009, 20:01:13 EST by Ms Lynette Adams on behalf of School of Biomedical Sciences