Synthesis of versatile thiol-reactive polymer scaffolds via RAFT polymerization

Wong, Lingjuin, Boyer, Cyrille, Zhongfan, Jia, Hadi, Zareie M. and Bulmus, Volga (2008) Synthesis of versatile thiol-reactive polymer scaffolds via RAFT polymerization. Biomacromolecules, 9 7: 1934-1944. doi:10.1021/bm800197v

Author Wong, Lingjuin
Boyer, Cyrille
Zhongfan, Jia
Hadi, Zareie M.
Bulmus, Volga
Title Synthesis of versatile thiol-reactive polymer scaffolds via RAFT polymerization
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
Publication date 2008-06-20
Year available 2008
Sub-type Article (original research)
DOI 10.1021/bm800197v
Volume 9
Issue 7
Start page 1934
End page 1944
Total pages 11
Place of publication Washington, DC, U.S.
Publisher American Chemical Society
Language eng
Subject 06 Biological Sciences
0605 Microbiology
Abstract Well-defined polymer scaffolds convertible to (multi)functional polymer structures via selective and efficient modifications potentially provide an easy, versatile, and useful approach for a wide variety of applications. Considering this, a homopolymer scaffold, poly(pyridyldisulfide ethylmethacrylate) (poly(PDSM)), having pendant groups selectively reactive with thiols, was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. Soluble polymers with controlled molecular weights and narrow PDIs were generated efficiently. The versatility of the scaffold to generate random co- and ter-polymers combining multiple functionalities with controlled-composition was shown by separate and simultaneous conjugation of different mercapto-compounds, including a tripeptide in one-step. Conversion of water-insoluble scaffold to peptide-containing water-soluble copolymers was observed to yield nanometer-size particles with narrow polydispersity. The overall results suggest that the well-defined PDSM homopolymer scaffold generated via RAFT polymerization can be a versatile building block for generation of new structures having potential for drug delivery applications via a straightforward synthetic approach.
Keyword Biochemistry & Molecular Biology
Chemistry, Organic
Polymer Science
Biochemistry & Molecular Biology
Polymer Science
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 94 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 99 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 21 Dec 2009, 19:00:32 EST by Rosalind Blair on behalf of Aust Institute for Bioengineering & Nanotechnology