New insights into nevogenesis: In vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy

Pellacani, G., Scope, A., Ferrari, B., Pupelli, G., Bassoli, S., Longo, C., Cesinaro, A. M., Argenziano, G., Hofmann-Wellenhof, R., Malvehy, J., Marghoob, A. A., Puig, S., Seidenari, S., Soyer, H. P. and Zalaudek, I. (2009) New insights into nevogenesis: In vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy. Journal of the American Academy of Dermatology, 61 6: 1001-1013. doi:10.1016/j.jaad.2009.04.018


Author Pellacani, G.
Scope, A.
Ferrari, B.
Pupelli, G.
Bassoli, S.
Longo, C.
Cesinaro, A. M.
Argenziano, G.
Hofmann-Wellenhof, R.
Malvehy, J.
Marghoob, A. A.
Puig, S.
Seidenari, S.
Soyer, H. P.
Zalaudek, I.
Title New insights into nevogenesis: In vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy
Journal name Journal of the American Academy of Dermatology   Check publisher's open access policy
ISSN 0190-9622
Publication date 2009-12-01
Sub-type Article (original research)
DOI 10.1016/j.jaad.2009.04.018
Volume 61
Issue 6
Start page 1001
End page 1013
Total pages 13
Editor Bruce H. Thiers
Place of publication United States of America
Publisher Mosby, Inc.
Language eng
Subject C1
920117 Skin and Related Disorders
110304 Dermatology
Abstract Abstract BACKGROUND: Development of melanocytic nevi is a complex process. OBJECTIVE: The aim of the study was to characterize the in vivo confocal microscopy patterns and histopathologic correlates of melanocytic nevi. In addition, for the first time, confocal follow-up of characteristic nevi was performed documenting histologic changes in nevi. METHODS: For the correlation study, 33 melanocytic nevi showing characteristic dermatoscopic patterns were studied by confocal microscopy. For the follow-up study 20 nevi were monitored for 12 to 18 months. RESULTS: Reticular nevi showed two different confocal patterns, ringed and meshwork, mostly corresponding to lentiginous and nested junctional patterns, respectively. Globular nevi presented large junctional clusters, whereas cobblestone nevi were constituted by dermal dense melanocytic clusters. Homogeneous nevi did not show distinctive confocal and histopathologic findings. Nevi with a rim of globules presented a meshwork pattern with junctional clusters at the periphery. At the confocal follow-up study all lesions showed limited dynamic changes resulting in stable dermatoscopic and confocal patterns, but 3 globular nevi with junctional nests at baseline evolved into reticular-meshwork pattern nevi with peripheral rim of globules-junctional nests. LIMITATIONS: Longer confocal follow-up of more melanocytic nevi is required to confirm this theory and to validate our preliminary findings. CONCLUSIONS: A model explaining the nevus classification and patterns of evolution of nevi observed in the study was proposed.
Keyword Follow-up
Histopathology
Nevogenesis
Nevus evolution
Reflectance confocal microscopy
Scanning Laser Microscopy
Biopsied junctional nevi
Pigmented skin-lesions
Dermoscopic Patterns
Age Distribution
Dual Concept
Features
Classification
Abtropfung
Melanomas
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Sun, 20 Dec 2009, 10:02:09 EST