Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

Thal, Dietmar Rudolf, Griffin, W. Sue T., de Vos, Rob A. I. and Ghebremedhin, Estifanos (2008) Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease. Acta Neuropathologica, 115 6: 599-609. doi:10.1007/s00401-008-0366-2

Author Thal, Dietmar Rudolf
Griffin, W. Sue T.
de Vos, Rob A. I.
Ghebremedhin, Estifanos
Title Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease
Journal name Acta Neuropathologica   Check publisher's open access policy
ISSN 0001-6322
Publication date 2008-06-01
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00401-008-0366-2
Volume 115
Issue 6
Start page 599
End page 609
Total pages 11
Place of publication Heidelberg, Germany
Publisher Springer Berlin
Language eng
Subject 11 Medical and Health Sciences
1109 Neurosciences
Formatted abstract
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid β-protein (Aβ) within cerebral vessels. The involvement of diVerent brain areas in CAA follows a hierarchical sequence similar to that of Alzheimer-related senile plaques. Alzheimer’s disease patients frequently exhibit CAA. The expansion of CAA in AD often shows the pattern of full-blown CAA. The deposition of Aβ within capillaries distinguishes two types of CAA. One with capillary Aβ-deposition is characterized by a strong association with the apolipoprotein E (APOE) ε4 allele and by its frequent occurrence in Alzheimer’s disease cases whereas the other one lacking capillary Aβ-deposits is not associated with APOE ε4. Capillary CAA can be seen in every stage of CAA or AD-related Aβ-deposition. AD cases with capillary CAA show more widespread capillary Aβ-deposition than non-demented cases as well as capillary occlusion. In a mouse model of CAA, capillary CAA was associated with capillary occlusion and cerebral blood Xow disturbances. Thus, blood Xow alterations with subsequent hypoperfusion induced by CAA-related capillary occlusion presumably point to a second mechanism in which Aβ adversely aVects the brain in AD in addition to its direct neurotoxic eVects.
Keyword Drainage
Cerebral amyloid angiopathy
Amyloid β-protein
Cerebral blood Xow
Alzheimer’s disease
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 130 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 16 Dec 2009, 22:15:08 EST by Macushla Boyle on behalf of Faculty of Science