The assessment of diffused light illumination and acetic acid rinse (Microlux/DL (TM)) in the visualisation of oral mucosal lesions

McIntosh, Lydija, McCullough, Michael J. and Farah, Camile S. (2009) The assessment of diffused light illumination and acetic acid rinse (Microlux/DL (TM)) in the visualisation of oral mucosal lesions. Oral Oncology, 45 12: E227-E231. doi:10.1016/j.oraloncology.2009.08.001


Author McIntosh, Lydija
McCullough, Michael J.
Farah, Camile S.
Title The assessment of diffused light illumination and acetic acid rinse (Microlux/DL (TM)) in the visualisation of oral mucosal lesions
Formatted title
The assessment of diffused light illumination and acetic acid rinse (Microlux/DL (™) in the visualisation of oral mucosal lesions
Journal name Oral Oncology   Check publisher's open access policy
ISSN 1368-8375
Publication date 2009-12-01
Sub-type Article (original research)
DOI 10.1016/j.oraloncology.2009.08.001
Open Access Status Not Open Access
Volume 45
Issue 12
Start page E227
End page E231
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject C1
920113 Oro-Dental Disorders
110505 Oral Medicine and Pathology
Abstract Oral examination alone cannot always distinguish benign from premalignant and malignant lesions, thereby resulting in delayed patient referral and poorer prognosis. Thus, any non-invasive technology which highlights oral premalignant and malignant lesions in a highly sensitive and specific manner will undoubtedly aid clinicians in early diagnosis and treatment of these conditions. The aim of this study was to assess the efficacy of acetic acid mouthwash and diffused light illumination (Microlux/DL) as a diagnostic aid in the visualisation of oral mucosal lesions and its ability to highlight malignant and potentially malignant lesions. Fifty patients referred for assessment of an oral white lesion were initially examined under routine incandescent operatory light. The location, size, ease of visibility, border distinctness and presence of satellite lesions were recorded. Clinical examination was repeated using the Microlux/DL diffused light illumination kit. An incisional biopsy was performed to provide a definitive histopathological diagnosis. Microlux/DL examination enhanced the visibility of 34 lesions, however, it did not help uncover any clinically undetected lesions, change the provisional diagnosis, or alter the biopsy site. Microlux/DL showed a sensitivity of 77.8% and a specificity of 70.7%, with a positive predictive value of 36.8%. Although Microlux/DL appears useful at enhancing lesion visibility, it is a poor discriminator for inflammatory, traumatic and malignant lesions.
Keyword Oral mucosal disorders
Oral cancer detection
Oral examination adjuncts
Acetic acid mouthwash
Microlux
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
ERA 2012 Admin Only
School of Dentistry Publications
 
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Created: Sun, 06 Dec 2009, 10:01:42 EST