Lung cancer risk in nonsmokers and GSTM1 and GSTT1 genetic polymorphism

Malats, Nuria, Camus-Radon, Anne-Marie, Nyberg, Fredrik, Ahrens, Wolfgang, Constantinescu, Vali, Mukeria, Anush, Benhamou, Ssimone, Batura-Gabryel, Halina, Bruske-Hohlfeld, Irene, Simonato, Lorenzo, Menezes, Ana, Lea, Suzanne, Lang, Matti and Boffetta, Paolo (2000) Lung cancer risk in nonsmokers and GSTM1 and GSTT1 genetic polymorphism. Cancer Epidemiology, Biomarkers and Prevention, 9 8: 827-833.

Author Malats, Nuria
Camus-Radon, Anne-Marie
Nyberg, Fredrik
Ahrens, Wolfgang
Constantinescu, Vali
Mukeria, Anush
Benhamou, Ssimone
Batura-Gabryel, Halina
Bruske-Hohlfeld, Irene
Simonato, Lorenzo
Menezes, Ana
Lea, Suzanne
Lang, Matti
Boffetta, Paolo
Title Lung cancer risk in nonsmokers and GSTM1 and GSTT1 genetic polymorphism
Formatted title
Lung cancer risk in nonsmokers and GSTM1 and GSTT1 genetic polymorphism
Journal name Cancer Epidemiology, Biomarkers and Prevention   Check publisher's open access policy
ISSN 1055-9965
Publication date 2000-08-01
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 9
Issue 8
Start page 827
End page 833
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher American Association for Cancer Research
Language eng
Formatted abstract
Glutathione S-transferase (GST) polymorphism may contribute to the individual variability in detoxifying lung carcinogens. This effect might be particularly relevant at low-level exposure to environmental carcinogens, such as in nonsmokers exposed to environmental tobacco smoke (ETS). We conducted a case-control study among 122 nonsmoking lung cancer cases and 121 nonsmoking controls from eight countries. Information on environmental exposures was obtained through a personal interview. The presence of GSTM1 and GSTT1 genes was determined using multiplex PCR. GSTM1-positive samples were then analyzed for *1A and* 1B polymorphism using an allele-specific amplification-PCR method. GSTM1*2 (null) individuals had an odds ratio (OR) of lung cancer of 1.5 [95% confidence interval (CI), 0.9–2.7]; the risk associated with this genotype was higher for cases with squamous and small cell carcinomas (OR, 2.3; 95% CI, 0.9–6.1) than for cases with adenocarcinomas. It was also elevated in individuals with long-term exposure to indoor wood combustion (OR, 3.1; 95% CI, 0.9–9.9), in subjects who mainly lived in a rural setting (OR, 3.6; 95% CI, 1.0–13), and in cases exposed to occupational carcinogens (OR, 10.7; 96% CI, 0.4–260) but not in subjects exposed to ETS. GSTT1*2 subjects did not show a risk of lung cancer. Our study suggests that the effect of GSTM1 polymorphism in nonsmokers is similar to that found in smokers. It does not seem to interact with ETS exposure, although we cannot exclude that it does in association with exposure to other specific environmental carcinogens.
Keyword Environmental tobacco smoke
S-transferase M1
Passive smoking
Bladder cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
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Created: Tue, 01 Dec 2009, 01:06:23 EST