Immunogenetic characteristics of immunoglobulin E in allergic disease

Davies, J. M. and O'Hehir, R. E. (2008) Immunogenetic characteristics of immunoglobulin E in allergic disease. Clinical And Experimental Allergy, 38 4: 566-578. doi:10.1111/j.1365-2222.2008.02941.x

Author Davies, J. M.
O'Hehir, R. E.
Title Immunogenetic characteristics of immunoglobulin E in allergic disease
Journal name Clinical And Experimental Allergy   Check publisher's open access policy
ISSN 1365-2222
Publication date 2008-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1365-2222.2008.02941.x
Volume 38
Issue 4
Start page 566
End page 578
Total pages 13
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Subject 11 Medical and Health Sciences
1107 Immunology
Abstract Patients with allergic diseases produce an excess of allergen-specific IgE, the specific effector molecule that triggers allergic reactions. The provocation for this excess IgE production is still uncertain. Current ideas include oligoclonal expansion of allergen-specific B cells emanating from germinal centres, activation by superantigen of a subset of B cells, or polyclonal B cells class switching to IgE due to an IL-4 predominance. Additionally, genetic elements contribute to a propensity for increased allergen-specific IgE production. The procedure of RT-PCR allows for amplification of infrequent IgE mRNA transcripts from B cells of atopic individuals, and so facilitates examination of expressed Ig cDNA sequences. Better knowledge of the molecular characteristics of IgE produced by patients with allergic diseases would elucidate the immunogenetic basis for elevated allergen-specific IgE levels. The 'immunogenetic footprint' of IgE transcripts may elucidate the origin and activation of IgE-producing B cells in allergic disease. Here we review studies of the immunogenetic features of IgE in allergic diseases, highlighting the major advances and the experimental limitations.
Keyword Class-switch recombination
Peripheral-blood lymphocytes
Germline gene transcripts
Heavy-chain repertoire
3 Unrelated patients
House dust mite
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Faculty of Health and Behavioural Sciences -- Publications
Excellence in Research Australia (ERA) - Collection
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 23 Nov 2009, 22:34:50 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences