A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?

Li, A. M. M. Y., Gomersall, C. D., Choi, G., Tian, Q., Joynt, G. M. and Lipman, J. (2009) A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?. Journal of Antimicrobial Chemotherapy, 64 5: 929-937. doi:10.1093/jac/dkp302


Author Li, A. M. M. Y.
Gomersall, C. D.
Choi, G.
Tian, Q.
Joynt, G. M.
Lipman, J.
Title A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
1460-2091
Publication date 2009-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/jac/dkp302
Open Access Status Not Open Access
Volume 64
Issue 5
Start page 929
End page 937
Total pages 9
Editor Alan P. Johnson
Place of publication London, United Kingdom
Publisher Oxford University Press
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
Background:
Drug dosing for septic patients with acute renal failure receiving continuous renal replacement therapy (CRRT) is complicated, and failure to correctly dose may result in either drug toxicity or treatment failure and development of antibiotic resistance. The aim of this study was to establish an ideal dataset that needs to be reported when presenting pharmacokinetic data for these patients and review current literature for completeness of this dataset.

Methods:
An ideal dataset was established of the parameters that should be reported when calculating a drug dosing regimen from first principles. A Medline search was performed of relevant literature producing 64 citations from which completeness of the specified criteria was examined.

Results:
None of the studies analysed presented the full dataset that we established as necessary. Of concern, basic pharmacokinetic parameters such as volume of distribution (Vd) and clearance (CL) were specified in only 79% and 81% of studies, respectively.

Conclusions:

A large proportion of current studies do not report key information necessary to devise a rational dosing regimen for patients with acute renal failure receiving CRRT, and we hope this dataset will be a useful guide when reporting future pharmacokinetic data.
Keyword Antibiotics
Drug dosing
Pharmacokinetics
Renal replacement therapy
Sepsis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number dkp302

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Sun, 22 Nov 2009, 10:03:51 EST