Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation

Lathia, Justin D., Okun, Eitan, Tang, Sung-Chun, Griffioen, Kathleen, Cheng, Aiwu, Mughal, Mohamed R., Laryea, Gloria, Selvaraj, Pradeep K., ffrench-Constant, Charles, Magnus, Tim, Arumugam, Thiruma V. and Mattson, Mark P. (2008) Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. Journal of Neuroscience, 28 51: 13978-13984. doi:10.1523/JNEUROSCI.2140-08.2008

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Author Lathia, Justin D.
Okun, Eitan
Tang, Sung-Chun
Griffioen, Kathleen
Cheng, Aiwu
Mughal, Mohamed R.
Laryea, Gloria
Selvaraj, Pradeep K.
ffrench-Constant, Charles
Magnus, Tim
Arumugam, Thiruma V.
Mattson, Mark P.
Title Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2008-12-17
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.2140-08.2008
Open Access Status File (Publisher version)
Volume 28
Issue 51
Start page 13978
End page 13984
Total pages 7
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Formatted abstract
Toll-like receptors (TLRs) play important roles in innate immunity. Several TLR family members have recently been shown to be expressed by neurons and glial cells in the adult brain, and may mediate responses of these cells to injury and infection. To address the possibility that TLRs play a functional role in development of the nervous system, we analyzed the expression of TLRs during different stages of mouse brain development and assessed the role of TLRs in cell proliferation. TLR3 protein is present in brain cells in early embryonic stages of development, and in cultured neural stem/progenitor cells (NPC). NPC from TLR3-deficient embryos formed greater numbers of neurospheres compared with neurospheres from wild-type embryos. Numbers of proliferating cells, as assessed by phospho histone H3 and proliferating cell nuclear antigen labeling, were also increased in the developing cortex of TLR3-deficient mice compared with wild-type mice in vivo. Treatment of cultured embryonic cortical neurospheres with a TLR3 ligand (polyIC) significantly reduced proliferating (BrdU-labeled) cells and neurosphere formation in wild type but not TLR3−/−-derived NPCs. Our findings reveal a novel role for TLR3 in the negative regulation of NPC proliferation in the developing brain.
Keyword Stem cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Created: Tue, 17 Nov 2009, 22:21:52 EST