Effect of Antimalarial Drugs on Plasmodium falciparum Gametocytes

Peatey, Christopher L., Skinner-Adams, Tina S., Dixon, Matthew W. A., McCarthy, James S., Gardiner, Donald L. and Trenholme, Katharine R. (2009) Effect of Antimalarial Drugs on Plasmodium falciparum Gametocytes. The Journal of Infectious Diseases, 200 10: 1518-1521. doi:10.1086/644645

Author Peatey, Christopher L.
Skinner-Adams, Tina S.
Dixon, Matthew W. A.
McCarthy, James S.
Gardiner, Donald L.
Trenholme, Katharine R.
Title Effect of Antimalarial Drugs on Plasmodium falciparum Gametocytes
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
Publication date 2009-11-01
Year available 2009
Sub-type Article (original research)
DOI 10.1086/644645
Open Access Status
Volume 200
Issue 10
Start page 1518
End page 1521
Total pages 4
Editor L. Powers
Place of publication United States
Publisher University of Chicago Press
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
110309 Infectious Diseases
Abstract Gametocytes are the sexual stage of the malaria parasite and are essential for transmission to the mosquito. Antimalarial drugs have been reported to affect gametocyte production in vivo, which leads to a potential increase in transmission. We used transgenic Plasmodium falciparum parasites expressing a green fluorescent protein tag in a fluorescence-activated cell sorting-based assay to measure the effect of 8 antimalarial drugs on gametocyte production in vitro. Exposure to antimalarial drugs resulted in an increase in the number of gametocytes in test cultures. Although a dose-dependent reduction in late-stage gametocyte viability was observed, none of the drugs tested statistically significantly reduced gametocyte numbers
Keyword Public, Environmental & Occupational Health
Tropical Medicine
Public, Environmental & Occupational Health
Tropical Medicine
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID NCRR12609
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 46 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 52 times in Scopus Article | Citations
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Created: Thu, 12 Nov 2009, 21:51:54 EST by Mr Andrew Martlew on behalf of Medicine - Princess Alexandra Hospital