Bladder dysfunction in multiple sclerosis.

McCombe, Pamela A., Gordon TP and Jackson MW (2009) Bladder dysfunction in multiple sclerosis.. Expert Rev Neurother., 9 3: 331-340. doi:10.1586/14737175.9.3.331

Author McCombe, Pamela A.
Gordon TP
Jackson MW
Title Bladder dysfunction in multiple sclerosis.
Journal name Expert Rev Neurother.   Check publisher's open access policy
ISSN 1473-7175
Publication date 2009-03-01
Year available 2009
Sub-type Article (original research)
DOI 10.1586/14737175.9.3.331
Volume 9
Issue 3
Start page 331
End page 340
Total pages 10
Editor Lucy Tipton
Elisa Manzotti
Place of publication United Kingdom
Publisher Expert Reviews Ltd.
Subject C1
Abstract Multiple sclerosis (MS) is a relatively common disease of young adults. Patients with MS can have a wide range of symptoms and may develop significant disability. The cause of MS is unknown, but immunological mechanisms are important. In MS, the pathological features include prominent demyelination and inflammation, but there is also evidence of neurodegeneration. Bladder symptoms are common in MS. The bladder is under neural control, and bladder disturbance is usually attributed to demyelination or loss of axons from the neural pathways, particularly those in the spinal cord, that control the bladder. However, as with other symptoms in MS, the presence of bladder disturbance does not always correlate well with MRI lesions. We speculate that other possible causes of bladder dysfunction in MS might include the effects of circulating toxic factors. Urgency of micturition is prominent in MS, and better understanding of the receptors involved in bladder sensation suggests possible treatment strategies through inhibiting these receptors.
Keyword bladder dysfunction
multiple sclerosis
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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Created: Mon, 12 Oct 2009, 23:08:05 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research