Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging

Huang, Hao, Xue, Rong, Zhang, Jiangyang, Ren, Tianbo, Richards, Linda J., Yarowsky, Paul, Miller, Michael I. and Mori, Susumu (2009) Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging. The Journal of Neuroscience, 29 13: 4263-4273. doi:10.1523/JNEUROSCI.2769-08.2009

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Author Huang, Hao
Xue, Rong
Zhang, Jiangyang
Ren, Tianbo
Richards, Linda J.
Yarowsky, Paul
Miller, Michael I.
Mori, Susumu
Title Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.2769-08.2009
Open Access Status File (Publisher version)
Volume 29
Issue 13
Start page 4263
End page 4273
Total pages 11
Editor Maunsell, John H. R.
Place of publication Washington, DC, United States
Publisher Society of Neuroscience
Language eng
Subject C1
110903 Central Nervous System
110902 Cellular Nervous System
920111 Nervous System and Disorders
Abstract Thehumanbrain is extraordinarily complex, and yet its origin is a simple tubular structure. Characterizing its anatomy at different stages of human fetal brain development not only aids in understanding this highly ordered process but also provides clues to detecting abnormalities caused by genetic or environmental factors. During the second trimester of human fetal development, neural structures in the brain undergo significant morphological changes. Diffusion tensor imaging (DTI), a novel method of magnetic resonance imaging, is capable of delineating anatomical components with high contrast and revealing structures at the microscopic level. In this study, high-resolution and high-signal-to-noise-ratio DTI data of fixed tissues of second-trimester human fetal brains were acquired and analyzed. DTI color maps and tractography revealed that important white matter tracts, such as the corpus callosum and uncinate and inferior longitudinal fasciculi, become apparent during this period. Three-dimensional reconstruction shows that major brain fissures appear while most of the cerebral surface remains smooth until the end of the second trimester. A dominant radial organization was identified at 15 gestational weeks, followed by both laminar and radial architectures in the cerebral wall throughout the remainder of the second trimester. Volumetric measurements of different structures indicate that the volumes of basal ganglia and ganglionic eminence increase along with that of the whole brain, while the ventricle size decreases in the later second trimester. The developing fetal brain DTI database presented can be used for education, as an anatomical research reference, and for data registration.
Keyword Neurosciences
Neurosciences & Neurology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID EB003543
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 141 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 153 times in Scopus Article | Citations
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Created: Thu, 10 Sep 2009, 23:48:52 EST by Debra McMurtrie on behalf of Queensland Brain Institute