Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion

Grattan, D. R., Steyn, F. J., Kokay, I. C., Anderson, G. M. and Bunn, S. J. (2008) Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion. Journal of Neuroendocrinology, 20 4: 497-507. doi:10.1111/j.1365-2826.2008.01661.x

Author Grattan, D. R.
Steyn, F. J.
Kokay, I. C.
Anderson, G. M.
Bunn, S. J.
Title Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion
Journal name Journal of Neuroendocrinology   Check publisher's open access policy
ISSN 0953-8194
Publication date 2008-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1365-2826.2008.01661.x
Volume 20
Issue 4
Start page 497
End page 507
Total pages 11
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Language eng
Subject 06 Biological Sciences
1101 Medical Biochemistry and Metabolomics
Abstract During pregnancy, neuroendocrine control of prolactin secretion is markedly altered to allow a state of hyperprolactinaemia to develop. Prolactin secretion is normally tightly regulated by a short-loop negative-feedback mechanism, whereby prolactin stimulates activity of tuberoinfundibular dopamine (TIDA) neurones to increase dopamine secretion into the pituitary portal blood. Dopamine inhibits prolactin secretion, thus reducing prolactin concentrations in the circulation back to the normal low level. Activation of this feedback secretion by placental lactogen during pregnancy maintains relatively low levels of prolactin secretion during early and mid-pregnancy. Despite the continued presence of placental lactogen, however, dopamine secretion from TIDA neurones is reduced during late pregnancy. Moreover, the neurones become completely unresponsive to endogenous or exogenous prolactin at this time, allowing a large nocturnal surge of prolactin to occur from the maternal pituitary gland during the night before parturition. In this review, we describe the changing patterns of prolactin secretion during pregnancy in the rat, and discuss the neuroendocrine mechanisms controlling these changes. The loss of response to prolactin is an important maternal adaptation to pregnancy, allowing the prolonged period of hyperprolactinaemia required for mammary gland development and function and for maternal behaviour immediately after parturition, and possibly also contributing to a range of other adaptive responses in the mother.
Keyword Prolactin Secretion
Neuroendocrine Responses
Placental lactogen
Tuberoinfundibular dopamine neurones
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 62 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 08 Sep 2009, 20:32:07 EST by Therese Egan on behalf of School of Biomedical Sciences