Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: Implications for retinoid balance in gonad development

Bowles, Josephine, Feng, Chun-Wei, Knight, Deon, Smith, Craig A., Roeszler, Kelly N., Bagheri-Fam, Stefan, Harley, Vincent R., Sinclair, Andrew H. and Koopman, Peter (2009) Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: Implications for retinoid balance in gonad development. Developmental Dynamics, 238 8: 2073-2080. doi:10.1002/dvdy.22024


Author Bowles, Josephine
Feng, Chun-Wei
Knight, Deon
Smith, Craig A.
Roeszler, Kelly N.
Bagheri-Fam, Stefan
Harley, Vincent R.
Sinclair, Andrew H.
Koopman, Peter
Title Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: Implications for retinoid balance in gonad development
Formatted title
 Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: Implications for retinoid balance in gonad development
Journal name Developmental Dynamics   Check publisher's open access policy
ISSN 1097-0177
1058-8388
Publication date 2009-08-01
Year available 2009
Sub-type Article (original research)
DOI 10.1002/dvdy.22024
Open Access Status Not yet assessed
Volume 238
Issue 8
Start page 2073
End page 2080
Total pages 8
Editor Gary C. Schoenwolf
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Language eng
Subject 0604 Genetics
0605 Microbiology
C1
970106 Expanding Knowledge in the Biological Sciences
060403 Developmental Genetics (incl. Sex Determination)
Abstract Balanced production and degradation of retinoids is important in regulating development of several organ systems in the vertebrate embryo. Among these, it is known that retinoic acid (RA), and the retinoid-catabolyzing enzyme CYP26B1 together regulate the sex-specific behavior of germ cells in developing mouse gonads. We report here that the gene encoding a cytosolic class-1 aldehyde dehydrogenase, ALDH1A1, a weak catalyst of RA production, is strongly expressed in a male-specific manner in somatic cells of the developing mouse testis, beginning shortly after Sry expression is first detectable. This expression pattern is conserved in the developing male gonad of the chicken and is dependent on the testis-specific transcription factor SOX9. Our data suggest that low levels of RA may be required for early developmental events in the testis, or that Aldh1a1 expression in the fetus may prefigure a later requirement for ALDH1A1 in regulating spermatogenesis postnatally. Developmental Dynamics 238:2073-2080, 2009. (C) 2009 Wiley-Liss, Inc.
Formatted abstract
Balanced production and degradation of retinoids is important in regulating development of several organ systems in the vertebrate embryo. Among these, it is known that retinoic acid (RA), and the retinoid-catabolyzing enzyme CYP26B1 together regulate the sex-specific behavior of germ cells in developing mouse gonads. We report here that the gene encoding a cytosolic class-1 aldehyde dehydrogenase, ALDH1A1, a weak catalyst of RA production, is strongly expressed in a male-specific manner in somatic cells of the developing mouse testis, beginning shortly after Sry expression is first detectable. This expression pattern is conserved in the developing male gonad of the chicken and is dependent on the testis-specific transcription factor SOX9. Our data suggest that low levels of RA may be required for early developmental events in the testis, or that Aldh1a1 expression in the fetus may prefigure a later requirement for ALDH1A1 in regulating spermatogenesis postnatally.
Keyword Aldh1a1
Testis development
Mouse testis
Chicken testis
Retinoic acid
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID ID334314
Institutional Status UQ

 
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Created: Fri, 04 Sep 2009, 20:24:57 EST