Human methyl parathion poisoning

Isbister, Geoffrey K., Mills, Katie, Friberg, Lena E., Hodge, Mary, O'Connor, Enda, Patel, Renu, Abeyewardene, Manel and Eddleston, Michael (2007) Human methyl parathion poisoning. Clinical Toxicology, 45 8: 956-960. doi:10.1080/15563650701232745

Author Isbister, Geoffrey K.
Mills, Katie
Friberg, Lena E.
Hodge, Mary
O'Connor, Enda
Patel, Renu
Abeyewardene, Manel
Eddleston, Michael
Title Human methyl parathion poisoning
Journal name Clinical Toxicology   Check publisher's open access policy
ISSN 1556-3650
Publication date 2007-12-01
Sub-type Article (original research)
DOI 10.1080/15563650701232745
Open Access Status Not Open Access
Volume 45
Issue 8
Start page 956
End page 960
Total pages 5
Place of publication New York, NY, United States
Publisher Informa Healthcare
Language eng
Subject 111506 Toxicology (incl.Clinical Toxicology)
Abstract Background. Methyl parathion is classed as an extremely hazardous pesticide with a rodent LD50 of 6 to 24 mg/kg. It has been banned in numerous countries, but there are few reports of acute methyl parathion poisoning. Methods. Plasma cholinesterase and acetylcholinesterase were measured in blood. Methyl parathion and the major metabolite 4-nitrophenol where measured in serum and urine. Based on the available concentration-time data, the pharmacokinetic parameters of methyl parathion were estimated for this patient. Case Report and Results. A 29-year-old male ingested 50 to 100mL (12 to 24 g) of methyl parathion causing delayed and prolonged suppression of acetylcholinesterase but almost no clinical effects. Absorption was predicted to last for 30 hours and the bioavailability appeared to be very low. Conclusions. Although it is feasible the patient ingested much less, a tenth of his alleged ingestion dose is more than the oral LD50 in rats. Methyl parathion appears to be less toxic in humans than parathion for similar amounts ingested, which is not consistent with the two pesticides having similar rodent LD50.
Keyword organophosphorous pesticide
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Pharmacy Publications
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