Immunosuppression by mesenchymal stromal cells: From culture to clinic

Jones, Ben J. and McTaggart, Steven J. (2008) Immunosuppression by mesenchymal stromal cells: From culture to clinic. Experimental Hematology, 36 6: 733-741. doi:10.1016/j.exphem.2008.03.006


Author Jones, Ben J.
McTaggart, Steven J.
Title Immunosuppression by mesenchymal stromal cells: From culture to clinic
Journal name Experimental Hematology   Check publisher's open access policy
ISSN 0301-472X
1873-2399
Publication date 2008-06-01
Sub-type Article (original research)
DOI 10.1016/j.exphem.2008.03.006
Open Access Status Not Open Access
Volume 36
Issue 6
Start page 733
End page 741
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 11 Medical and Health Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Extensive in vitro studies have shown that multipotent mesenchymal stromal cells (MSC) can exert profound immunosuppressive effects via modulation of both cellular and innate immune pathways. Their ability to be readily isolated from a number of tissues and expanded ex vivo makes them attractive candidates for systemic immunosuppressive therapy. In this article, we will review recent experimental data on the mechanisms by which MSC inhibit the alloproliferative response and the clinical relevance for their potential use in hematopoietic stem cell transplantation, solid organ transplantation, and treatment of autoimmune diseases. While in vitro data consistently demonstrate the immunosuppressive capability of MSC, current studies in animals and humans suggest that MSC are less effective in producing systemic immunosuppression. Further mechanistic studies and randomized controlled trials using standardized cell populations are needed to define the optimal conditions for the use of MSC as immunotherapy. © 2008 ISEH - Society for Hematology and Stem Cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 20:01:23 EST by Mr Andrew Martlew on behalf of Mater Clinical School