Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype

English, Dallas R., Young, Joanne P., Simpson, Julie A., Jenkins, Mark A., Southey, Melissa C., Walsh, Michael D., Buchanan, Daniel D., Barker, Melissa A., Haydon, Andrew M., Royce, Simon G., Roberts, Aedan, Parry, Susan, Hopper, John L., Jass, JeremyJ. and Giles, Graham G. (2008) Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. Cancer Epidemiology Biomarkers and Prevention, 17 7: 1774-1780. doi:10.1158/1055-9965.EPI-08-0091


Author English, Dallas R.
Young, Joanne P.
Simpson, Julie A.
Jenkins, Mark A.
Southey, Melissa C.
Walsh, Michael D.
Buchanan, Daniel D.
Barker, Melissa A.
Haydon, Andrew M.
Royce, Simon G.
Roberts, Aedan
Parry, Susan
Hopper, John L.
Jass, JeremyJ.
Giles, Graham G.
Title Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype
Formatted title
Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype
Journal name Cancer Epidemiology Biomarkers and Prevention   Check publisher's open access policy
ISSN 1055-9965
1538-7755
Publication date 2008-07-01
Year available 2014
Sub-type Article (original research)
DOI 10.1158/1055-9965.EPI-08-0091
Open Access Status Not Open Access
Volume 17
Issue 7
Start page 1774
End page 1780
Total pages 7
Place of publication Philadelphia, PA, U.S.A.
Publisher American Association for Cancer Research
Language eng
Formatted abstract
Colorectal cancers arising from serrated polyps are characterized by the CpG island methylator phenotype (CIMP) and somatic mutation (V600E) in the BRAF proto-oncogene. Few epidemiologic studies have investigated risk factors for these tumors. We conducted a cohort study of 41,328 residents of Melbourne, Australia that included 9,939 participants of southern European origin and 31,389 of Anglo-Celtic origin. Colorectal adenocarcinomas were identified from population-based cancer registries. BRAF V600E mutation in tumors was determined using a PCR-based allelic discrimination method. Tumors were classified as CIMP positive when at least three of five markers (RUNX3, CACNA1G, SOCS1, NEUROG1, and IGF2) were methylated according to MethyLight analysis. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated by Cox regression with adjustment for risk factors for colorectal cancer. During follow-up, 718 participants were diagnosed with colorectal cancer. CIMP assays were done for 579 and BRAF V600E mutation testing for 582. After adjustment for other risk factors, when compared with people of Anglo-Celtic origin, those of southern European origin had lower incidence of colorectal cancer that had CIMP (HR, 0.32; 95% CI, 0.16-0.67) or BRAF mutations (HR, 0.30; 95% CI, 0.16-0.58) but similar incidence of colorectal cancer without CIMP (HR, 0.86; 95% CI, 0.70-1.05) or BRAF (HR, 0.90; 95% CI, 0.74-1.11). People of southern European origin had lower risk of colorectal cancers with CIMP and BRAF mutation than people of Anglo-Celtic origin, which may in part be due to genetic factors that are less common in people of southern European origin.
Keyword Colorectal cancer
CpG island methylator phenotype
BRAF mutation
Ethnicity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 442965
1025268
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
ERA 2012 Admin Only
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 66 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 65 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 03 Sep 2009, 19:50:01 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences