Differential time- and frequency-dependent structure of postural sway and finger tremor in Parkinson's disease

Morrison, S., Kerr, G., Newell, K. M. and Silburn, P. A. (2008) Differential time- and frequency-dependent structure of postural sway and finger tremor in Parkinson's disease. Neuroscience Letters, 443 3: 123-128. doi:10.1016/j.neulet.2008.07.071


Author Morrison, S.
Kerr, G.
Newell, K. M.
Silburn, P. A.
Title Differential time- and frequency-dependent structure of postural sway and finger tremor in Parkinson's disease
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2008-10-01
Sub-type Article (original research)
DOI 10.1016/j.neulet.2008.07.071
Volume 443
Issue 3
Start page 123
End page 128
Total pages 6
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland
Language eng
Subject 1109 Neurosciences
1103 Clinical Sciences
Abstract The time- and frequency-dependent patterns of standing balance centre of pressure (COP) and finger postural/resting tremor of 12 older individuals and eight age-matched Parkinsonian (PD) participants (on/off medication) were investigated. Tremor and COP data were analysed using measures of signal amplitude (RMS), time-dependent structure (approximate entropy, ApEn), time–frequency analysis and synchrony (Cross ApEn). Results showed that the PD individuals had significantly greater tremor amplitude and COP excursions in comparison to controls. Differences in the time-dependent structure were also observed between groups. In comparison to the elderly, the resting/postural tremor output of the PD subjects was more regular (lower ApEn). However, for the postural measures, a reciprocal pattern was observed with the COP being more complex (higher ApEn). All group differences were magnified when the PD individuals were off their medication. There was also greater synchrony between tremor and postural sway for the PD individuals, indicating a high degree of association between these motor outputs. These results are consistent with the view that the neural signal driving the enhanced limb tremor in PD is propagated throughout the motor system, consequently emerging within the postural sway dynamics. This commonality of motor output may be a contributing factor in the differential pattern in the dynamics of effector signal structure in PD as a function of task.
Keyword Parkinson's disease
Tremor
Postural sway
Regularity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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