Sleep disturbances in CHARGE syndrome: types and relationships with behavior and caregiver well-being

Hartshorne, T. S., Heussler, H. S., Dailor, A. N., Williams, G. L., Papadopoulos, D. and Brandt, K. K. (2009) Sleep disturbances in CHARGE syndrome: types and relationships with behavior and caregiver well-being. Developmental Medicine and Child Neurology, 51 2: 143-150. doi:10.1111/j.1469-8749.2008.03146.x


Author Hartshorne, T. S.
Heussler, H. S.
Dailor, A. N.
Williams, G. L.
Papadopoulos, D.
Brandt, K. K.
Title Sleep disturbances in CHARGE syndrome: types and relationships with behavior and caregiver well-being
Journal name Developmental Medicine and Child Neurology   Check publisher's open access policy
ISSN 0012-1622
1469-8749
Publication date 2009-02-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1469-8749.2008.03146.x
Volume 51
Issue 2
Start page 143
End page 150
Total pages 8
Place of publication London, United Kingdom
Publisher Mac Keith Press
Language eng
Subject 11 Medical and Health Sciences
1114 Paediatrics and Reproductive Medicine
C1
970111 Expanding Knowledge in the Medical and Health Sciences
Abstract Children with CHARGE syndrome frequently develop moderate to severe behavior difficulties and are often diagnosed with obsessive–compulsive disorder, attention deficit disorder, Tourette syndrome, and autism. Anecdotal reports have indicated that sleep is also affected. However, the prevalence and types of sleep disturbance have not been identified. This study investigated sleep disturbances in 87 children with CHARGE syndrome, aged 6 to 18 years (mean 11y, SD 3y 8mo). There were 52 males and 35 females represented. Instruments included measures of sleep (Sleep Disturbances Scale for Children [SDSC]), behavior (Developmental Behaviour Checklist [DBC]), and carer well-being (Malaise Inventory). On the SDSC, 57.5% received scores considered significant for sleep disturbances, with disorders of initiating and maintaining sleep, sleep breathing, and sleep–wake transition being the most common. The SDSC was significantly correlated with the DBC (p=0.010) and the Malaise Inventory (p=0.003). Regression analysis found that both problem behavior and sleep disturbances contributed to the prediction of scores on the Malaise Inventory. Being both deaf and blind (p=0.001), experiencing frequent middle-ear infections (p=0.015), and starting to walk at an older age (p=0.007) were associated with more sleep disturbance. Craniofacial anomalies were not. The study highlights the importance of addressing the sleep difficulties associated with CHARGE syndrome relating both to airway management and to disorders of initiating sleep. Copyright © 2009 Mac Keith Press
Keyword Choanal atresia
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 19:01:09 EST by Mr Andrew Martlew on behalf of Medicine - Princess Alexandra Hospital