Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

Battle, Andrew R, Valenzuela, Stella M, Mechler, Adam, Nichols, Ryan J, Praporski, Slavica, Di Maio, Isabelle L, Islam, Hedayetul, Cirard-Egrot, Agnes P, Cornell, Bruce A, Prashar, Jog, Caruso, Frank, Martin, Lisandra L and Martin, Donald K (2009) Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane. Advanced Functional Materials, 19 2: 201-208. doi:10.1002/adfm.200800483


Author Battle, Andrew R
Valenzuela, Stella M
Mechler, Adam
Nichols, Ryan J
Praporski, Slavica
Di Maio, Isabelle L
Islam, Hedayetul
Cirard-Egrot, Agnes P
Cornell, Bruce A
Prashar, Jog
Caruso, Frank
Martin, Lisandra L
Martin, Donald K
Title Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane
Journal name Advanced Functional Materials   Check publisher's open access policy
ISSN 1616-301X
1616-3028
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1002/adfm.200800483
Open Access Status
Volume 19
Issue 2
Start page 201
End page 208
Total pages 8
Editor David Flanagan
Lisa Wylie
Place of publication Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Language eng
Subject C1
920106 Endocrine Organs and Diseases (excl. Diabetes)
060110 Receptors and Membrane Biology
Abstract The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules Is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated Into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.
Keyword colorectal-cancer cells
multilayered particles
capsules
vesicles
bilayers
surface
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Thu, 03 Sep 2009, 18:53:26 EST by Mr Andrew Martlew on behalf of School of Biomedical Sciences