Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet

Wang, Jian-qing, Li, Jun, Zou, Yu-hong, Cheng, Wen-ming, Lu, Chao, Zhang, Lei, Ge, Jin-fang, Huang, Cheng, Jin, Yong, Lv, Xiong-wen, Hu, Cheng-mu and Liu, Li-ping (2009) Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet. Journal Of Ethnopharmacology, 121 1: 54-60. doi:10.1016/j.jep.2008.09.029


Author Wang, Jian-qing
Li, Jun
Zou, Yu-hong
Cheng, Wen-ming
Lu, Chao
Zhang, Lei
Ge, Jin-fang
Huang, Cheng
Jin, Yong
Lv, Xiong-wen
Hu, Cheng-mu
Liu, Li-ping
Title Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet
Journal name Journal Of Ethnopharmacology   Check publisher's open access policy
ISSN 0378-8741
Publication date 2009-01-12
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.jep.2008.09.029
Volume 121
Issue 1
Start page 54
End page 60
Total pages 7
Place of publication Lausanne
Publisher Elsevier Sequoia
Language eng
Subject 03 Chemical Sciences
Formatted abstract
Aim of the study
To evaluate the protective effects of total flavonoids of Litsea Coreana leve (TFLC) on rat high fat diet-induced hepatic steatosis model.

Materials and methods

Rats were given either a high fat diet alone or the same diet plus TFLC for 4 weeks.

Results

TFLC improved liver histology with reduced serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as decreased the over accumulation lipids in serum and liver. TFLC increased serum levels of leptin and insulin, while decreased serum TNFα level in high fat diet fed rat. Furthermore, TFLC was found increased the expression of peroxisome proliferator-activated receptor α (PPARα) in high fat diet fed rat liver. These benefits were associated with increased superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in high fat diet fed rat liver.

Conclusions

TFLC exerts protective effects against hepatic steatosis in rats fed with high fat diet possibly through its antioxidant actions, improving the adipocytokines release and increasing the expression of PPARα.
Keyword Flavonoids
Activated Receptor-alpha
Litsea coreana leve
Adipocytokines
PPARĪ±
Antioxidants
Hepatic steatosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 03 Sep 2009, 18:50:14 EST by Mr Andrew Martlew on behalf of School of Chemistry & Molecular Biosciences