Synthesis and evaluation of partly fluorinated block copolymers as MRI imaging agents

Peng, Hui, Blakey, IIdriss, Dargaville, Bronwin, Rasoul, Firas, Rose, Stephen and Whittaker, Andrew K. (2009) Synthesis and evaluation of partly fluorinated block copolymers as MRI imaging agents. Biomacromolecules, 10 2: 374-381. doi:10.1021/bm801136m

Author Peng, Hui
Blakey, IIdriss
Dargaville, Bronwin
Rasoul, Firas
Rose, Stephen
Whittaker, Andrew K.
Title Synthesis and evaluation of partly fluorinated block copolymers as MRI imaging agents
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
Publication date 2009-02-01
Year available 2009
Sub-type Article (original research)
DOI 10.1021/bm801136m
Volume 10
Issue 2
Start page 374
End page 381
Total pages 8
Editor Ann-Christine Albertsson
Place of publication Washington, DC, U.S.
Publisher American Chemical Society
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
110320 Radiology and Organ Imaging
Abstract A series of well-defined diblock copolymers of acrylic acid with partially fluorinated acrylate and methacrylate monomers were synthesized using ATRP as potential 19F MRI imaging agents. The diblock copolymers could undergo spontaneous self-assembly in mixed and aqueous solvents to form stable micelles with a diameter from approximately 20−45 nm, having a fluorine-rich core that provides a strong signal for MRI examinations. The observed MRI image intensities were related to the NMR longitudinal and transverse relaxation times, and were found to depend on polymer structure and method of micellization. Two distinct T2 relaxation times were measured; on comparison of expected MRI image intensities with those observed experimentally, it was found that methacrylate polymers show systematically lower signal intensity than acrylate polymers. This is related to the presence of a population of nuclear spins having very short T2 relaxation times that cannot be detected under high-resolution NMR and MRI conditions.
Keyword Transfer radical polymerization
longitudinal relaxation times
transverse relaxation times
MRI image intensity
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Thu, 03 Sep 2009, 18:46:46 EST by Mr Andrew Martlew on behalf of Aust Institute for Bioengineering & Nanotechnology