Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice

Beverdam, Annemiek, Svingen, Terje, Bagheri-Fam, Stefan, Bernard, Pascal, McClive, Peter, Robson, Mathew, Khojasteh, Mahdi Banan, Salehi, Mahboubeh, Sinclair, Andrew H., Harley, Vincent R. and Koopman, Peter (2009) Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice. Reproduction, 137 3: 481-486. doi:10.1530/REP-08-0336


Author Beverdam, Annemiek
Svingen, Terje
Bagheri-Fam, Stefan
Bernard, Pascal
McClive, Peter
Robson, Mathew
Khojasteh, Mahdi Banan
Salehi, Mahboubeh
Sinclair, Andrew H.
Harley, Vincent R.
Koopman, Peter
Title Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice
Journal name Reproduction   Check publisher's open access policy
ISSN 1470-1626
Publication date 2009-03-01
Sub-type Article (original research)
DOI 10.1530/REP-08-0336
Volume 137
Issue 3
Start page 481
End page 486
Total pages 6
Place of publication Bristol, England
Publisher BioScientifica
Collection year 2009
Language eng
Subject 06 Biological Sciences
C1
970106 Expanding Knowledge in the Biological Sciences
Abstract Glutathione S-transferases (GSTs) are an important family of multifunctional enzymes that play a role in the protection of tissues by the detoxification of hazardous and carcinogenic compounds. We found previously that Gstm6 is upregulated in the somatic cells of male mouse fetal gonads relative to female gonads. In this study, we describe the spatial and temporal expression pattern of Gstm6 during mouse development. We show that Gstm6 is predominantly expressed in the reproductive system, at significantly higher levels in XY gonads compared with XX gonads from 11.5 dpc onwards, and remains expressed in the testes in adult mice. Its expression is associated with the Sertoli cell lineage, and is dependent on the expression of the male sex-determining gene Sox9. Our data suggest that Gstm6 plays a male-specific role in gonad development or function, possibly by modulating the exposure of somatic tissue and/or germ cells to endogenous or exogenous toxicants.
Keyword sex determination reveals
mullerian hormone gene
mouse testis
candidate genes
differentiation
SOX9
SRY
transcription
proliferation
granulosa
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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