Biocompatible polypeptide microcapsules via templating mesoporous silica spheres

Yu, Aimin, Gentle, Ian R. and Lu, Gao Qing (Max) (2009) Biocompatible polypeptide microcapsules via templating mesoporous silica spheres. Journal of Colloid and Interface Science, 333 1: 341-345. doi:10.1016/j.jcis.2009.01.036

Author Yu, Aimin
Gentle, Ian R.
Lu, Gao Qing (Max)
Title Biocompatible polypeptide microcapsules via templating mesoporous silica spheres
Journal name Journal of Colloid and Interface Science   Check publisher's open access policy
ISSN 0021-9797
Publication date 2009-01-24
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.jcis.2009.01.036
Open Access Status Not yet assessed
Volume 333
Issue 1
Start page 341
End page 345
Total pages 5
Editor Darsh T Wasan
Place of publication United States
Publisher Academic Press
Language eng
Subject C1
030603 Colloid and Surface Chemistry
030304 Physical Chemistry of Materials
970103 Expanding Knowledge in the Chemical Sciences
Abstract We reported the stepwise formation of biocompatible poly(L-lysine)/poly(L-glutamic acid) (PLL/PGA) multilayer films on mesoporous silica (MS) spheres via layer-by-layer (LbL) self-assembly technique. In-situ QCM revealed the nonlinear (exponential) growth of PLL/PGA multilayer films at both pH 5.5 and pH 7.0 conditions. xi-Potential measurements of the multilayer coated particles indicated that the multilayer surface was being charge-overcompensated in each adsorption step, thereby facilitating adsorption of the next oppositely charged polypeptide onto the MS spheres. Hollow polypeptide capsules could be obtained by Subsequently removing silica cores in HF solution. By using enzyme-preloaded MS spheres as capsule templates, a general approach was developed for encapsulating enzymes in biocompatible microcapsules with high loading and retained bioactivity. The loading amount for several enzymes with different sizes and their bioactivity after encapsulation were also reported. (c) 2009 Elsevier Inc. All rights reserved.
Keyword Biocompatible hollow capsules
Mesoporous silica
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP0770686
Institutional Status UQ

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Created: Thu, 03 Sep 2009, 18:21:24 EST by Mr Andrew Martlew on behalf of School of Chemistry & Molecular Biosciences