Automated reporting of eGFR: A useful tool for identifying and managing kidney disease

Johnson, David W., Jones, Graham R. D., Becker, Gavin J. and Mathew, Timothy H. (2009) Automated reporting of eGFR: A useful tool for identifying and managing kidney disease. Medical Journal of Australia, 190 4: 200-203.

Author Johnson, David W.
Jones, Graham R. D.
Becker, Gavin J.
Mathew, Timothy H.
Title Automated reporting of eGFR: A useful tool for identifying and managing kidney disease
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 2009-02-16
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 190
Issue 4
Start page 200
End page 203
Total pages 4
Place of publication Strawberry Hills, NSW, Australia
Publisher Australasian Medical Publishing Company
Language eng
Formatted abstract
• Estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease formula has been shown to provide unbiased and acceptably accurate estimates of measured GFR across a broad range of individuals with impaired kidney function.
• eGFR is superior to measuring serum creatinine (SCr) concentration alone, more accurate than other prediction formulas (such as Cockcroft-Gault) in the setting of reduced kidney function, and more practical and reliable under most circumstances than measuring urinary creatinine clearance.
• Routine eGFR reporting with requests for SCr, in concert with clinician education, has been shown to enhance the detection of chronic kidney disease (CKD), resulting in improved cardiac and renal outcomes for patients.
• eGFR has been shown to effectively identify individuals at increased risk of adverse drug reactions (even when SCr concentration is in the normal range). For most drugs prescribed in primary care and for most patients of average age and body size, drug dosage adjustments based on eGFR should be similar to those based on Cockcroft-Gault. eGFR should not replace Cockcroft-Gault for determining dosage adjustments for critical-dose drugs that have a narrow therapeutic index.
• eGFR has resulted in important spin-off benefits, such as standardisation of laboratory creatinine assays and enhanced public and clinician awareness of CKD.
• Clinicians should be aware of the strengths, weaknesses and appropriate use of eGFR. Considerable research effort is being directed towards further refinement of eGFR.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
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Created: Thu, 03 Sep 2009, 18:20:28 EST by Mr Andrew Martlew on behalf of Medicine - Princess Alexandra Hospital