eGFR - use beyond the evidence

Martin, JH, Fay, MF and Ungerer, JP (2009) eGFR - use beyond the evidence. MEDICAL JOURNAL OF AUSTRALIA, 190 4: 197-199.


Author Martin, JH
Fay, MF
Ungerer, JP
Title eGFR - use beyond the evidence
Journal name MEDICAL JOURNAL OF AUSTRALIA   Check publisher's open access policy
ISSN 0025-729X
Publication date 2009-02-16
Year available 2009
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 190
Issue 4
Start page 197
End page 199
Total pages 3
Editor M. Van Der Weyden
Place of publication Australia
Publisher Australasian Med Pub Co
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
1115 Pharmacology and Pharmaceutical Sciences
Abstract The estimated glomerular filtration rate (eGFR) algorithm has some advantages over serum creatinine concentration for estimating GFR. There are a number of caveats around the use of eGFR, predominantly because it assumes subjects are of average body size and similar lean body weight. eGFR has not been validated as a safe method of adjusting drug dosing, nor as a screening test for impaired renal function in the general population. eGFR has not been validated as a robust measure of kidney function in many groups (eg, older people, inpatients, differing racial groups, obese people). eGFR is inaccurate in many settings, such as in high, low or rapidly changing GFRs. Until evidence of safety and efficacy is provided, eGFR should not be used for calculating drug doses, and use of the Cockcroft-Gault formula or other validated methods should continue.
Keyword GLOMERULAR-FILTRATION-RATE
chronic kidney disease
Cystatin-C
Enoxaparin
Creatine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 18:20:25 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute