Efficacy of the EG95 hydatid vaccine in a macropodid host, the tammar wallaby

Barnes, T. S., Hinds, L. A., Jenkins, D. J., Coleman, G. T., Colebrook, A. L., Kyngdon, C. T., Gauci, C. G. and Lightowlers, M. W. (2009) Efficacy of the EG95 hydatid vaccine in a macropodid host, the tammar wallaby. Parasitology, 136 4: 461-468. doi:10.1017/S0031182009005526

Author Barnes, T. S.
Hinds, L. A.
Jenkins, D. J.
Coleman, G. T.
Colebrook, A. L.
Kyngdon, C. T.
Gauci, C. G.
Lightowlers, M. W.
Title Efficacy of the EG95 hydatid vaccine in a macropodid host, the tammar wallaby
Journal name Parasitology   Check publisher's open access policy
ISSN 0031-1820
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1017/S0031182009005526
Open Access Status DOI
Volume 136
Issue 4
Start page 461
End page 468
Total pages 8
Editor Phillips, R. S.
Gasser, R. B.
Chappell, L. H.
Place of publication London
Publisher Cambridge University Press
Language eng
Subject 070705 Veterinary Immunology
070708 Veterinary Parasitology
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Abstract In Australia, macropodids are common intermediate hosts for the cestode Echinococcus granulosus, and sylvatic transmission is maintained via wild dogs. The parasite causes mortality in a number of macropodid species and the sylvatic cycle provides a source of infection to domestic livestock and humans. We determined the efficacy of the hydatid vaccine, EG95 in the tammar wallaby, Macropus eugenii, challenging either 1 or 9 months post-vaccination. EG95 provides similar protection to that seen in sheep (96-100%). Control tammars were significantly more likely to become infected (odds ratio 29.44; CI 4.13, 209.97; P=0.001) and to develop more cysts (count ratio 26.69; CI 5.83, 122.19; P<0.001). The vaccination may be beneficial if administered pre-release in captive breeding programmes for endangered macropodids. Further work to develop oral delivery methods may enable vaccine administration of wild animals and thereby a reduction in sylvatic transmission.
Keyword Echinococcus granulosus
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID ARCLP0668354
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 18:17:31 EST by Mr Andrew Martlew on behalf of School of Veterinary Science