Evaluation of haemocompatibility of TLM titanium alloy with surface heparinization

Yu, S., Yu, Z. T., Wang, G., Dargusch, M. S. and Zhang, M. H. (2009) Evaluation of haemocompatibility of TLM titanium alloy with surface heparinization. Rare Metal Materials and Engineering, 38 3: 384-388. doi:10.1016/S1875-5372(10)60023-9

Author Yu, S.
Yu, Z. T.
Wang, G.
Dargusch, M. S.
Zhang, M. H.
Title Evaluation of haemocompatibility of TLM titanium alloy with surface heparinization
Journal name Rare Metal Materials and Engineering
ISSN 1002-185X
Publication date 2009-03-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/S1875-5372(10)60023-9
Open Access Status
Volume 38
Issue 3
Start page 384
End page 388
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject C1
8612 Fabricated Metal Products
091207 Metals and Alloy Materials
Abstract A layer of TiO2 film was prepared by sol-gel method on the surface of TLM(Ti-3Zr-2Sn-3Mo-25Nb) alloy. Then the coated samples were treated by hydroxyl solution and amination solution in order to introduce the OH- and NH2- active groups, and the heparin was linked on the surface of TiO2 film through these active groups. The phase identification and the surface characteristics of the samples were successively undertaken using XRD, SEM and EDS. The in vitro blood compatibility of the TLM alloy specimens with and without heparinization treatments was evaluated by the contact angle test, the hemolysis test and investigation of their platelet adhesion behavior. The results showed that the haemocompatibility of the TLM alloy could be significantly improved by surface modification via heparinization.
Keyword Haemocompatibility
TLM alloy
Surface Modification
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 2005CB623904
Institutional Status UQ

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Created: Thu, 03 Sep 2009, 18:17:25 EST by Mr Andrew Martlew on behalf of School of Mechanical and Mining Engineering