Comparison of adiponectin, leptin and, leptin to adiponectin ratio as, diagnostic marker for metabolic syndrome in older adults of Chinese major cities

Zhuo, Qin, Wang, Zhiqiang, Fu, Ping, Piao, Jianhua, Tian, Yuan, Xu, Jie and Yang, Xiaoguang (2009) Comparison of adiponectin, leptin and, leptin to adiponectin ratio as, diagnostic marker for metabolic syndrome in older adults of Chinese major cities. Diabetes Research and Clinical Practice, 84 1: 27-33. doi:10.1016/j.diabres.2008.12.019


Author Zhuo, Qin
Wang, Zhiqiang
Fu, Ping
Piao, Jianhua
Tian, Yuan
Xu, Jie
Yang, Xiaoguang
Title Comparison of adiponectin, leptin and, leptin to adiponectin ratio as, diagnostic marker for metabolic syndrome in older adults of Chinese major cities
Journal name Diabetes Research and Clinical Practice   Check publisher's open access policy
ISSN 0168-8227
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.diabres.2008.12.019
Open Access Status DOI
Volume 84
Issue 1
Start page 27
End page 33
Total pages 7
Editor N. Hotta
Place of publication Ireland
Publisher Elsevier Ireland Ltd
Language eng
Subject C1
Abstract The aim of this study was to compare the strength of association between metabolic syndrome (MetS) and adiponectin, leptin and leptin to adiponectin ratio (L/A) in older Chinese. This study included 950 males (220 with MetS) and 1096 females (452 with MetS), aged 60–96 years from 18 major cities of the 2002 China National Nutrition and Health Survey. The associations of adiponectin, leptin and L/A with components of MetS and MetS were examined using logistic regression and the receiver operating characteristic (ROC) curves. The correlation coefficients of MetS components except fasting glucose with leptin were similar to those with L/A and higher than those with adiponectin. After adjusting for age and BMI, the odds ratio for MetS corresponding to 1 SD change in L/A was higher than those for leptin and adiponectin. L/A had highest area under the curve (AUC) for MetS. However, there was no statistically significant difference in AUC between leptin and L/A, and both indices produced a significantly higher AUC than adiponectin. In conclusion, L/A and leptin may be better diagnostic markers for MetS than adiponectin. After adjusting for BMI, L/A has better ability for correctly classifying subjects with and without MetS than adiponectin or leptin alone.
Formatted abstract
The aim of this study was to compare the strength of association between metabolic syndrome (MetS) and adiponectin, leptin and leptin to adiponectin ratio (L/A) in older Chinese. This study included 950 males (220 with MetS) and 1096 females (452 with MetS), aged 60–96 years from 18 major cities of the 2002 China National Nutrition and Health Survey. The associations of adiponectin, leptin and L/A with components of MetS and MetS were examined using logistic regression and the receiver operating characteristic (ROC) curves. The correlation coefficients of MetS components except fasting glucose with leptin were similar to those with L/A and higher than those with adiponectin. After adjusting for age and BMI, the odds ratio for MetS corresponding to 1 SD change in L/A was higher than those for leptin and adiponectin. L/A had highest area under the curve (AUC) for MetS. However, there was no statistically significant difference in AUC between leptin and L/A, and both indices produced a significantly higher AUC than adiponectin. In conclusion, L/A and leptin may be better diagnostic markers for MetS than adiponectin. After adjusting for BMI, L/A has better ability for correctly classifying subjects with and without MetS than adiponectin or leptin alone.

Keyword Adiponectin
Insulin-resistance
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 30671750
511013
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 18:16:39 EST by Mr Andrew Martlew on behalf of Medicine - Royal Brisbane and Women's Hospital