Why schizophrenia epidemiology needs neurobiology - And vice versa

McGrath, John J. and Richards, Linda J. (2009) Why schizophrenia epidemiology needs neurobiology - And vice versa. Schizophrenia Bulletin, 35 3: 577-581. doi:10.1093/schbul/sbp004

Author McGrath, John J.
Richards, Linda J.
Title Why schizophrenia epidemiology needs neurobiology - And vice versa
Journal name Schizophrenia Bulletin   Check publisher's open access policy
ISSN 0586-7614
Publication date 2009-05-01
Year available 2009
Sub-type Article (original research)
DOI 10.1093/schbul/sbp004
Open Access Status DOI
Volume 35
Issue 3
Start page 577
End page 581
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract Schizophrenia epidemiology can provide us with valuable information to guide research directions. However, while epidemiology is useful for generating candidate risk factors, it can not always deliver studies that prove causality. We argue that the field needs more translational research that links schizophrenia epidemiology with molecular, cellular, and behavioral neuroscience. Cross-disciplinary projects related to candidate genetic or nongenetic risk factors not only can address the biological plausibility of these factors, but they can serve as catalysts for discovery in neuroscience. This type of cross disciplinary research is likely to be more efficient compared to clinically dislocated basic neuroscience. Examples of this type of translational research are provided based on (a) the impact of prenatal nutrition and prenatal infection on brain development and (b) understanding the causes and consequences of agenesis of the corpus callosum. We need to build shared discovery platforms that encourage greater cross-fertilization between schizophrenia epidemiology and basic neuroscience research.
Keyword Epidemiology
Developmental neurobiology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 03 Sep 2009, 18:15:14 EST by Mr Andrew Martlew on behalf of Queensland Brain Institute