Evaluating the accuracy and impact of registration in dynamic contrast-enhanced breast MRI

Hill, Andrew, Mehnert, Andrew, Crozier, Stuart and McMahon, Kerry (2009) Evaluating the accuracy and impact of registration in dynamic contrast-enhanced breast MRI. Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering, 35B 2: 106-120. doi:10.1002/cmr.b.20133


Author Hill, Andrew
Mehnert, Andrew
Crozier, Stuart
McMahon, Kerry
Title Evaluating the accuracy and impact of registration in dynamic contrast-enhanced breast MRI
Journal name Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering   Check publisher's open access policy
ISSN 1552-5031
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1002/cmr.b.20133
Open Access Status
Volume 35B
Issue 2
Start page 106
End page 120
Total pages 15
Editor Daniel D Traficante
Place of publication USA
Publisher John Wiley & Sons Inc
Language eng
Subject 080106 Image Processing
890299 Computer Software and Services not elsewhere classified
C1
Abstract This article presents a quantitative evaluation framework-incorporating a novel heterogeneous biomechanical model-for objectively comparing the accuracy of registration algorithms in dynamic contrast-enhanced (DCE) MRI of the breast; an evaluation of several algorithms using this framework; and several clinical examples where accurate registration significantly changes the shape of the enhancement curves associated with suspicious regions of interest (ROIs) identified by a radiologist. The experimental results demonstrate: (i) the efficacy of the evaluation framework; (ii) that a good registration algorithm can accurately recover the shapes of voxel enhancement curves from breast DCE-MRI data containing motion; (iii) that motion of as little as I mm can significantly change the shape of the mean enhancement curve for an ROI; and (iv) that accurate registration can significantly change the shape of enhancement curves estimated for small and large ROIs even when there is little or no visible evidence of motion. This suggests that all DCE-MRI breast data should be spatially aligned using a nonrigid registration algorithm before the analysis of contrast enhancement. (C) 2009 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 3513: 106-120, 2009
Keyword breast MRI
PRESERVING NONRIGID REGISTRATION
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP0879250
2006000185
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Information Technology and Electrical Engineering Publications
 
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Created: Thu, 03 Sep 2009, 18:14:23 EST by Mr Andrew Martlew on behalf of School of Information Technol and Elec Engineering