Does lactate level in the first 12 hours of life predict mortality in extremely premature infants?

Hussain, F., Gilshenan, K. and Gray, P.H. (2009) Does lactate level in the first 12 hours of life predict mortality in extremely premature infants?. Journal of Paediatrics and Child Health, 45 5: 263-267. doi:10.1111/j.1440-1754.2009.01488.x


Author Hussain, F.
Gilshenan, K.
Gray, P.H.
Title Does lactate level in the first 12 hours of life predict mortality in extremely premature infants?
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
Publication date 2009-05-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1440-1754.2009.01488.x
Open Access Status Not Open Access
Volume 45
Issue 5
Start page 263
End page 267
Total pages 5
Editor David Isaacs
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject C1
920501 Child Health
11 Medical and Health Sciences
Formatted abstract
Aims: To determine if high lactate levels within the first 12 h of life independently or in combination with Clinical Risk Index for Babies (CRIB) II can predict mortality in extremely premature babies.

Study Design: A retrospective review of medical charts of babies born between 2001 and 2003 with birthweight <1000 g or gestation <28 weeks was performed. Blood gases and highest umbilical lactate levels in first 12 h of life were noted. Area under the curve (AUC) was calculated for lactate, CRIB and CRIB II as a predictor of mortality. The AUC for lactate and CRIB II were combined using discriminant analysis.

Results: Two hundred nineteen infants were included in the study, 41 (18.7%) of whom died. The AUC for lactate was 0.67 (P < 0.001), while AUCs for CRIB and CRIB II score were 0.81 (P < 0.001) and 0.82 (P < 0.001), respectively. The AUC for the combined measure of lactate and CRIB II was 0.82, similar to CRIB II.

Conclusions
: Lactate predicts mortality in premature infants, but was found to be inferior to CRIB and CRIB II. Adding lactate level to CRIB II score does not improve its predictive ability.

Keyword CRIB
Birth-weight Infants
Lactate
Preterm Infant
Neurodevelopment
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 18:11:32 EST by Mr Andrew Martlew on behalf of Medicine - Princess Alexandra Hospital