An 'inside-out' approach to suramin analogues

McGeary, Ross P., Bennett, Andrew J., Tran, Quoc B., Prins, Johannes and Ross, Benjamin P. (2009) An 'inside-out' approach to suramin analogues. Tetrahedron, 65 20: 3990-3997. doi:10.1016/j.tet.2009.03.033

Author McGeary, Ross P.
Bennett, Andrew J.
Tran, Quoc B.
Prins, Johannes
Ross, Benjamin P.
Title An 'inside-out' approach to suramin analogues
Journal name Tetrahedron   Check publisher's open access policy
ISSN 0040-4020
Publication date 2009-03-21
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.tet.2009.03.033
Open Access Status Not yet assessed
Volume 65
Issue 20
Start page 3990
End page 3997
Total pages 8
Editor L. Ghosez
T. Lectka
S.F. Martin
W.B. Motherwell
G.P. Pandey
R.J.K. Taylor
K. Tomioka
Place of publication United Kingdom
Publisher Pergamon
Language eng
Subject C1
970103 Expanding Knowledge in the Chemical Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
0304 Medicinal and Biomolecular Chemistry
030503 Organic Chemical Synthesis
Abstract An approach to the synthesis of suramin analogues has been realised, which avoids synthetic problems associated with conventional routes. The use of isobutyl ester protecting groups for sulfonic acids was crucial to the success of the strategy, because these were able to be cleanly deprotected with sodium iodide, yielding the sodium salts of the corresponding sulfonic acids. (C) 2009 Elsevier Ltd. All rights reserved.
Keyword Suramin
Sulfonic acid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 03 Sep 2009, 18:08:05 EST by Mr Andrew Martlew on behalf of School of Chemistry & Molecular Biosciences