Assessment of Feasibility of Maillard Reaction between Baclofen and Lactose by Liquid Chromatography and Tandem Mass Spectrometry, Application to Pre Formulation Studies

Monajjemzadeh, F., Hassanzadeh, D., Valizadeh, H, Siahi-Shadbad, M. R., Mojarrad, J. S., Robertson, T. and Roberts, MS (2009) Assessment of Feasibility of Maillard Reaction between Baclofen and Lactose by Liquid Chromatography and Tandem Mass Spectrometry, Application to Pre Formulation Studies. AAPS PHARMSCITECH, 10 2: 649-659. doi:10.1208/s12249-009-9248-8


Author Monajjemzadeh, F.
Hassanzadeh, D.
Valizadeh, H
Siahi-Shadbad, M. R.
Mojarrad, J. S.
Robertson, T.
Roberts, MS
Title Assessment of Feasibility of Maillard Reaction between Baclofen and Lactose by Liquid Chromatography and Tandem Mass Spectrometry, Application to Pre Formulation Studies
Journal name AAPS PHARMSCITECH   Check publisher's open access policy
ISSN 1530-9932
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1208/s12249-009-9248-8
Open Access Status DOI
Volume 10
Issue 2
Start page 649
End page 659
Total pages 11
Editor Kirsch, L.
Place of publication United States
Publisher Springer New York LLC
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
1115 Pharmacology and Pharmaceutical Sciences
Abstract The aim of this study was to determine any possible, baclofen-lactose Maillard reaction products. Granules and tablets of baclofen and lactose were prepared and maintained in heat ovens for a certain time period. The effects of lactose type, addition of magnesium stearate, and water were monitored. Heated lactose and baclofen were analyzed using reverse-phase HPLC. Liquid chromatography tandem mass spectroscopy revealed nominal mass values consistent with baclofen-lactose, early-stage Maillard reaction condensation products (ESMRP). Multiple reaction monitoring confirmed the presence of ESMRP as well. FTIR analysis proved the formation of imine bond. The results indicated that baclofen undergoes a Maillard-type reaction with lactose.
Keyword baclofen
PHARMACEUTICAL GRANULAR LACTOSES
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 18:03:40 EST by Mr Andrew Martlew on behalf of Medicine - Princess Alexandra Hospital