Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system

Nayak, Usha Yogendra, Shavi, Gopal Venktesh, Nayak, Yogendra, Averinen, Ranjith Kumar, Mutalik, Srinivas, Reddy, Sreenivasa Meka, Gupta, Purshottam Das and Udupa, Nayanabhirama (2009) Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system. Journal of Controlled Release, 136 2: 125-131. doi:10.1016/j.jconrel.2009.02.008


Author Nayak, Usha Yogendra
Shavi, Gopal Venktesh
Nayak, Yogendra
Averinen, Ranjith Kumar
Mutalik, Srinivas
Reddy, Sreenivasa Meka
Gupta, Purshottam Das
Udupa, Nayanabhirama
Title Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system
Journal name Journal of Controlled Release   Check publisher's open access policy
ISSN 0168-3659
1873-4995
Publication date 2009-06-05
Sub-type Article (original research)
DOI 10.1016/j.jconrel.2009.02.008
Open Access Status
Volume 136
Issue 2
Start page 125
End page 131
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled delivery. In the majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulations with constant/programmable delivery rates make it possible to deliver drug at definite time or controlled rate in chronopharmacokinetic studies. The prepared system contained swellable polymer (l-hydroxypropyl cellulose (L-HPC), xanthan gum, polyethylene oxide or sodium alginate) together with drug tablet and erodible tablet (L-HPC or guar gum) in a pre-coated capsule. Various formulation factors were investigated through series of tests, in vitro dissolution and ex vivo continuous dissolution–absorption studies. We found that the type, amount of polymers and erodible tablet influenced the drug release. The formulation containing 200 mg sodium alginate and erodible tablet (150 mg) containing 50% guar gum and 46% lactose showed 5–6 h lag time and 10 ± 2.1% drug release in initial 6 h following rapid release (99 ± 1.7% release in 12 h) of drug was observed. The continuous dissolution–absorption study conducted using everted rat intestinal segment indicated delay in absorption of drug. Thus this approach can provide a useful means for timed release of valsartan and may be helpful for patients with morning surge.
Keyword Chronopharmacokinetic
Valsartan
Controlled delivery
Continuous dissolution–absorption
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Thu, 03 Sep 2009, 17:59:48 EST by Mr Andrew Martlew on behalf of School of Pharmacy